Using human genetics to understand the disease impacts of testosterone in men and women

KS Ruth, FR Day, J Tyrrell, DJ Thompson, AR Wood… - Nature medicine, 2020 - nature.com
… We also show adverse effects of higher testosterone on breast and endometrial cancers in
… cancer in men. Our findings provide insights into the disease impacts of testosterone and …

Testosterone in men with advanced liver disease: abnormalities and implications

M Sinclair, M Grossmann, PJ Gow… - … of gastroenterology and …, 2015 - Wiley Online Library
… is clearly required to evaluate both the impact of testosterone deficiency on clinical
outcomes and the safety and efficacy of testosterone therapy in men with chronic liver disease. …

[HTML][HTML] Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease

JF Reckelhoff, LL Yanes, R Iliescu… - American Journal …, 2005 - journals.physiology.org
… in testosterone with age and chronic disease is a protective mechanism against even greater
cardiovascular-renal disease … Therefore, androgen supplements in aging men could offset …

Testosterone and cardiovascular disease

RA Kloner, C Carson, A Dobs, S Kopecky… - Journal of the American …, 2016 - jacc.org
… The use of T in older men and those with known coronary artery disease is controversial.
Asymptomatic, middle-aged and older men without a history of heart disease should be …

Low serum testosterone and increased mortality in men with coronary heart disease

CJ Malkin, PJ Pugh, PD Morris, S Asif, TH Jones… - Heart, 2010 - heart.bmj.com
impact of testosterone status on all-cause mortality in men with pre-existing coronary disease,
testosterone deficiency in men with coronary disease. Our hypothesis was that low serum …

The causes of adverse changes of testosterone levels in men

M Wrzosek, J Woźniak, D Włodarek - Expert Review of …, 2020 - Taylor & Francis
… cardiovascular diseases or cancer, testosterone deficiency … factors may adversely impact
testosterone levels in men. … factors influencing testosterone level disorders in men. Although …

Low free testosterone predicts mortality from cardiovascular disease but not other causes: the Health in Men Study

Z Hyde, PE Norman, L Flicker… - The Journal of …, 2012 - academic.oup.com
… and cause-specific mortality in a cohort of men aged 70–88 yr at baseline. … diseases, cancer,
and all remaining causes (as a composite). We hypothesized that men with low testosterone

[HTML][HTML] Testosterone: a vascular hormone in health and disease

DM Kelly, TH Jones - Journal of Endocrinology, 2013 - joe.bioscientifica.com
… serum testosterone levels in men with cardiovascular disease (CVD). Furthermore, a low
testosterone … These data may therefore suggest that sub-normal levels of testosterone impact

Low testosterone in men with cardiovascular disease or risk factors: to treat or not to treat?

DC Cassimatis, MT Crim, NK Wenger - Current treatment options in …, 2016 - Springer
… randomized trial evaluating the impact of T replacement on MACE, for men both with and
without CV disease or CV risk factors. Clinicians should be aware that all men who elect to take …

Testosterone, cardiovascular disease and the metabolic syndrome

G Corona, G Rastrelli, L Vignozzi, E Mannucci… - Best practice & research …, 2011 - Elsevier
… of both men and women. The death rates from these diseases are higher in men. CVD …
syndrome and cardiovascular diseases, highlighting their mutual impact on patient's morbidity …