Disease modeling and drug screening for neurological diseases using human induced pluripotent stem cells

X Xu, Z Zhong - Acta Pharmacologica Sinica, 2013 - nature.com
… made to date on cellular disease modeling and drug screening using stem cell systems (ie, …
with neurological diseases. We review a few critical questions for disease modeling based …

Induced pluripotent stem cells as a disease modeling and drug screening platform

AD Ebert, P Liang, JC Wu - Journal of cardiovascular …, 2012 - journals.lww.com
… of small chemicals in drug development. This illustrates how iPSCs provide an improved
model system for disease modeling, high-throughput drug screening, and toxicity testing. …

3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling

X Ma, J Liu, W Zhu, M Tang, N Lawrence, C Yu… - Advanced drug delivery …, 2018 - Elsevier
… to build functional tissue models for in vitro drug screening and disease modeling. This review
… tissue models that can be used for personalized drug screening and disease modeling. In …

Current status of drug screening and disease modelling in human pluripotent stem cells

D Rajamohan, E Matsa, S Kalra, J Crutchley… - …, 2013 - Wiley Online Library
… the effects of drug treatment. Emerging technologies for scale-up, automation and high
throughput analysis will enable use of hiPSC-disease models for drug discovery and safety …

3D bioprinting for high-throughput screening: Drug screening, disease modeling, and precision medicine applications

A Mazzocchi, S Soker, A Skardal - Applied Physics Reviews, 2019 - pubs.aip.org
… on drug screening and toxicity studies, with additional interest in improving analyses of disease
models … With bioprinting as a tool, physiologically relevant models can be realized within …

Drug screening for human genetic diseases using iPSC models

MS Elitt, L Barbar, PJ Tesar - Human molecular genetics, 2018 - academic.oup.com
… unattainable in vitro disease modeling and subsequent drug screening studies. However, …
Medicine blog ‘In the pipeline’ for further clarity on drug screening-related considerations. …

[HTML][HTML] Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease

YS Chun, P Chaudhari, YY Jang - International journal of biological …, 2010 - ncbi.nlm.nih.gov
… More recently several groups have explored the possibilities of disease modeling using …
disease models but also drug screening and cell replacement therapy for various diseases. …

iPSCs as a platform for disease modeling, drug screening, and personalized therapy in muscular dystrophies

JL Ortiz-Vitali, R Darabi - Cells, 2019 - mdpi.com
… , iPSCs are a great candidate for disease modeling, drug screening, and gene correction.
iPSCs … S1) using the technologies for MD disease modeling and gene correction. We point out …

Engineered heart tissues and induced pluripotent stem cells: macro-and microstructures for disease modeling, drug screening, and translational studies

E Tzatzalos, OJ Abilez, P Shukla, JC Wu - Advanced drug delivery reviews, 2016 - Elsevier
… phenotype of the iPSC-CM as compared to the physiological disease phenotype… disease
model must also recapitulate physiological drug response in order to accurately evaluate drugs

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

A Skardal, T Shupe, A Atala - Drug discovery today, 2016 - Elsevier
… In this review, we highlight a variety of organoid-on-a-chip systems for applications such
as drug screening and disease models, and look to the future of multi-organoid body-on-a-chip …