… Diseases ) and hint to KHSRP modulation as a target of therapeutic intervention in inflammatory
diseases. … progression of myoblasts through the myogenic differentiation program45. …

… of non-histone targets. Several PRDM family members are deregulated in human diseases,
most … in the gene expression program consisting of repression of the mesoderm somatic …

… Thus, H19 lncRNA promotes myogenesis by generating a microRNA to inhibit this negative
regulator of muscle differentiation. The other microRNA, miR-675-5p, directly targets and …

… dysregulated metabolic programs, … disease pathogenesis acquired from mutational and
gene expression analyses have directed AML differentiation therapy to several novel targets…

… in disease. However, a growing understanding of the chromatin status of a critical class of
TGF-β target genes – the genes controlling differentiation … program of TGF-β in most cell types. …

… differentiation or somatic cells trans‐differentiation is a promising approach for cell replacement
in neurodegenerative diseases … diseases, and uncovering the mechanisms that underlie …

… The underlying mechanism for BMP and Wnt regulation of regeneration and differentiation
resides in the cell-type-specific targets of the SMAD and TCF transcription factors, respectively…

… present multilevel molecular targets, identified during HSC self-renewal, differentiation and
… cells (LICs) and then replicate the disease in animal models. The pioneered studies of J. Dick …

… where a crucial disease-causing target can be identified or to … target that is due to a mutation,
which generates a target site, … roles in cellular differentiation programmes. Several miRNAs, …

… through a receptor complex of myeloid differentiation 2 (MD-2) … therapeutic target of
inflammatory and immune diseases in human… , under development to treat inflammatory diseases. …