[PDF][PDF] Plasticity of CD4+ T cell lineage differentiation

L Zhou, MMW Chong, DR Littman - Immunity, 2009 - cell.com
differentiation program of the T cells, which requires plasticity in the regulation of transcriptional
targets… of pathogenic Th1 cells in these and other disease models. It is also worthwhile to …

[HTML][HTML] Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model

P Xu, H He, Q Gao, Y Zhou, Z Wu… - The Journal of …, 2022 - Am Soc Clin Investig
… mDA neuron differentiation in vitro and graft composition in vivo, we revealed the developmental
basis of both target and off-target neuronal cells that emerge during differentiation and …

[HTML][HTML] MEF2 transcription factors regulate distinct gene programs in mammalian skeletal muscle differentiation

NL Estrella, CA Desjardins, SE Nocco, AL Clark… - Journal of biological …, 2015 - ASBMB
programs. These results suggest that individual MEF2 family members are able to recognize
specific targets … their respective gene programs in skeletal muscle homeostasis and disease.…

Clonal tracking in gene therapy patients reveals a diversity of human hematopoietic differentiation programs

E Six, A Guilloux, A Denis, A Lecoules… - Blood, The Journal …, 2020 - ashpublications.org
… Our results suggested that in at least 2 distinct genetic diseases, human hematopoiesis after
gene therapy is maintained by several distinct HSPC subsets, rather than a single subset of …

Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy

J Wei, S Bhattacharyya, WG Tourtellotte, J Varga - Autoimmunity reviews, 2011 - Elsevier
… , mediators and differentiation programs that are responsible for SSc … diseases and asthma.
Thus the PPAR-γ pathway represents an appealing therapeutic target in a variety of diseases

Notch in T cell differentiation: all things considered

D Amsen, C Helbig, RA Backer - Trends in immunology, 2015 - cell.com
… such diverse differentiation programs. Studies … target Notch in T cells for therapeutic
purposes. There are efforts to mitigate detrimental responses, such as in allergic asthma, a disease

The therapeutic contribution of nanomedicine to treat neurodegenerative diseases via neural stem cell differentiation

D Carradori, J Eyer, P Saulnier, V Préat, A Des Rieux - Biomaterials, 2017 - Elsevier
… gene expression in NSC by affecting intrinsic transcriptional programs (red arrows). Sonic …
, to target endogenous NSC. Indeed, strategies aiming at in situ differentiation of endogenous …

Guiding modern traditional Chinese medicine research using the theory of state‐target differentiation and treatment—Maintaining the validity of traditional Chinese …

J Lin, J Tian, X Fang, B Zhang, Y Yang… - Advanced Chinese …, 2024 - Wiley Online Library
disease target (target formula/herb with specific curative effects on diseases), symptom target
(target … on clinical symptoms), and indicator target (target formula/herb with special impact …

Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective

VK Rajasekhar, M Begemann - Stem cells, 2007 - academic.oup.com
… ES cell differentiation-specific gene expression programs [101… at the target DNA upon
induction of neuronal differentiation, … for activation during ES cell differentiation and that stem cell …

Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

A Melnick, JD Licht - Blood, The Journal of the American …, 1999 - ashpublications.org
… complete remissions by differentiation and eventual elimination of … , leading to in vivo
differentiation and clinical remission. … Finally, we will reconstruct the disease of APL and examine …