The effects of aging on host resistance and disease tolerance to SARSCoV‐2 infection

DZL Mok, CYY Chan, EE Ooi, KR Chan - The FEBS Journal, 2021 - Wiley Online Library
… aging can disrupt resistance and disease tolerance mechanisms. We explore how disruption
of such resistance and disease tolerance mechanisms underpin the association between …

Surviving COVID-19: A disease tolerance perspective

JS Ayres - Science advances, 2020 - science.org
… In early January 2020, a virus was sequenced and identified as a novel coronavirus
named SARS-CoV-2, the causative agent of COVID-19. By March 2020, the World Health …

Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARSCoV‐2

YH Chan, SW Fong, CM Poh, G Carissimo… - EMBO molecular …, 2021 - embopress.org
… against SARSCoV‐2 … SARSCoV‐2 indicative of disease tolerance. Insights from this
study highlight key immune pathways that could serve as therapeutic targets to prevent disease

[HTML][HTML] Innate lymphoid cells and disease tolerance in SARS-CoV-2 infection

NJ Silverstein, Y Wang, Z Manickas-Hill, C Carbone… - medRxiv, 2021 - ncbi.nlm.nih.gov
… amphiregulin, a protein implicated in disease tolerance and tissue homeostasis, and …
disease tolerance, homeostatic ILCs decrease morbidity and mortality associated with SARS-CoV-…

[HTML][HTML] Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract

T Flerlage, DF Boyd, V Meliopoulos… - Nature Reviews …, 2021 - nature.com
Disease tolerance refers to a host response that acts to limit … In the respiratory tract, a strategy
of tolerance would maintain … The concepts of resistance and tolerance are often employed …

Between immunomodulation and immunotolerance: The role of IFNγ in SARS-CoV-2 disease

N Todorović-Raković, JR Whitfield - Cytokine, 2021 - Elsevier
Tolerance refers to the capacity of a host to limit the damage caused by both, immune-… of
tolerance as a peculiar form of evolutionary adaptation. Enhanced infection tolerance may be …

SARS-CoV-2 infection relaxes peripheral B cell tolerance

MJ Castleman, MM Stumpf, NR Therrien… - Journal of Experimental …, 2022 - rupress.org
… stimuli can breach peripheral B cell tolerance in this subset. We asked whether SARS-CoV-2–associated
inflammation impairs B ND cell peripheral tolerance. To address this, PBMCs …

[HTML][HTML] SARS-CoV-2 infections in children: Understanding diverse outcomes

P Brodin - Immunity, 2022 - cell.com
… the differences in COVID-19 diseases severity in the young versus the … disease manifestations
and their possible disease … of SARS-CoV-2 infections in children and young people. …

SARS-CoV-2 triggering autoimmune diseases

L Mobasheri, MH Nasirpour, E Masoumi… - Cytokine, 2022 - Elsevier
… acute respiratory syndrome coronavirus 2 (SARS-CoV-2) … can contribute to autoimmune
disease, which has been … -reg by the SARS-CoV-2 reduces self-tolerance and leads to …

Safety and tolerance of vaccines against SARS-CoV-2 infection in systemic lupus erythematosus: results from the COVAD study

R Naveen, E Nikiphorou, M Joshi, P Sen… - …, 2023 - academic.oup.com
… Active and inactive disease state four weeks prior to … was the status of your autoimmune
disease in the four weeks (prior to) … disease were grouped together to designate ‘active disease’. …