Is COVID-19-associated cytokine storm distinct from non-COVID-19 secondary hemophagocytic lymphohistiocytosis?

JM Liu, J Chi - Experimental Biology and Medicine, 2022 - journals.sagepub.com
Cytokine storm is an umbrella term that describes an inflammatory syndrome characterized
… do not reveal a cytotoxicity defect but rather an inflammatory profile. Blood 2020;136:542–52 …

Cytokine profiles as potential prognostic and therapeutic markers in SARS-CoV-2-induced ARDS

F Salton, P Confalonieri, G Campisciano… - Journal of clinical …, 2022 - mdpi.com
… pulmonary and systemic inflammatory response, also referred to as a “cytokine storm,” that
… As a small preliminary study, we performed a time-course analysis in distinct time points …

The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge

M Buszko, JH Park, D Verthelyi, R Sen, HA Young… - Nature …, 2020 - nature.com
… the central roles of inflammation and a cytokine storm in causing … Merad then described
early results from deep-profiling … may generate a unique inflammatory milieu that promotes the …

Distinguishing immune activation and inflammatory signatures of multisystem inflammatory syndrome in children (MIS-C) versus hemophagocytic lymphohistiocytosis …

D Kumar, CA Rostad, P Jaggi, DSV Nunez… - Journal of Allergy and …, 2022 - Elsevier
… and multiplex cytokine and chemokine profiling, we evaluated … Our findings could help
understand the unique inflammatory … amplifying the cytokine storm in patients with MIS-C. Innate …

The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm

M Hamdorf, T Imhof, B Bailey-Elkin… - Journal of Molecular …, 2024 - academic.oup.com
… Therefore, we also analyzed the cytokine and chemokine expression profiles of monocyte-derived
DCs exposed to ORF8 during differentiation. Strikingly, compared with that in …

[HTML][HTML] The ACE2‐deficient mouse: A model for a cytokine storm‐driven inflammation

J Wang, N Kaplan, J Wysocki, W Yang, K Lu… - The FASEB …, 2020 - ncbi.nlm.nih.gov
… administration of such ACE2 have the potential as an ideal treatment, and Ace2 −/− mice
a unique model to study inflammatory processes akin to those observed in severe COVID‐19. …

Cytokine profiles in the detection of severe lung involvement in hospitalized patients with COVID-19: The IL-8/IL-32 axis

L Bergantini, M d'Alessandro, P Cameli, A Otranto… - Cytokine, 2022 - Elsevier
… to the cytokine storm in COVID-19 patients, highlighting different severity of … cytokine storm
in COVID-19 patients, highlighting specific cytokine signatures among patients with different

Influenza infection, SARS, MERS and COVID-19: cytokine storm–the common denominator and the lessons to be learned

VA Ryabkova, LP Churilov, Y Shoenfeld - Clinical Immunology, 2021 - Elsevier
… to the general inflammatory profile [17]. … inflammatory autacoids termed “cytokine storm
syndrome”, is very wide and includes both infectious and non-infectious diseases. While distinct

Looking into the IL-1 of the storm: are inflammasomes the link between immunothrombosis and hyperinflammation in cytokine storm syndromes?

TA Gleeson, E Nordling, C Kaiser… - Discovery …, 2022 - academic.oup.com
Cytokine storms occur in a variety of different settings including as an aberrant response
to … non-myelosuppressive safety profile, compared with other treatments trialled for use in …

Difference in mortality rates in hospitalized COVID-19 patients identified by cytokine profile clustering using a machine learning approach: An outcome prediction …

AC Castro-Castro, L Figueroa-Protti… - Frontiers in …, 2022 - frontiersin.org
… aforementioned cytokine storm (11, 12), different strategies to screen and modulate cytokine
… therapies to control the inflammatory process such as IL-6 receptor antagonists or systemic …