[HTML][HTML] Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

Y Wang, J Guo, G Ni, J Yang, PM Visscher… - Nature …, 2020 - nature.com
… Other factors such as population specific causal variants 11,… breeds as a function of population
parameters (eg heritability, … in an ancestry divergent sample as a function of population

Population differentiation of polygenic score predictions under stabilizing selection

S Yair, G Coop - … Transactions of the Royal Society B, 2022 - royalsocietypublishing.org
… In our models, we focus on divergence without gene flow between a pair of populations, in
which case they only share polymorphisms that arose in their common ancestor and were not …

No support for the hereditarian hypothesis of the Black–White achievement gap using polygenic scores and tests for divergent selection

KA Bird - American journal of physical anthropology, 2021 - Wiley Online Library
… This analysis employs the current most reliable methods given concerns over cross-population
polygenic score analysis. It demonstrates that patterns of genetic differences between …

Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences

NA Rosenberg, MD Edge, JK Pritchard… - … , medicine, and public …, 2019 - academic.oup.com
… or with different magnitudes in the same direction, and therefore need not increase genetic
differences between populations in the way that divergent selection for the initial trait might …

Divergent selection on height and cognitive ability: evidence from both genetic distance (Fst) and polygenic scores

D Piffer - 2021 - preprints.org
… -population variation and correlation with latitude to identify signals of polygenic adaptation
on two highly polygenic … The correlation of polygenic scores with average population trait (…

[PDF][PDF] Inclusion of variants discovered from diverse populations improves polygenic risk score transferability

TB Cavazos, JS Witte - Human Genetics and Genomics Advances, 2021 - cell.com
… ancestry populations. Our simulations show that the magnitude of this bias increases with
increasing divergence from European ancestry, and this is attributed to population differences …

Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians

R Avinun, A Nevo, SR Radtke, BD Brigidi… - European archives of …, 2020 - Springer
… As higher DA polygenic scores putatively index higher in vivo DA … DA polygenic scores
and lower depressive symptoms in the Duke Neurogenetics Study (DNS). To avoid population

[PDF][PDF] Low and differential polygenic score generalizability among African populations due largely to genetic diversity

L Majara, A Kalungi, N Koen, K Tsuo, Y Wang… - Human Genetics and …, 2023 - cell.com
… The lowest prediction accuracy is in populations with southern African ancestry, consistent
also with higher genetic divergence from European populations and more genetic diversity …

Clinical use of current polygenic risk scores may exacerbate health disparities

AR Martin, M Kanai, Y Kamatani, Y Okada, BM Neale… - Nature …, 2019 - nature.com
divergence from the makeup of the discovery GWAS; therefore, the accuracy … polygenic
scores in different populations is highly dependent on the representation of the study population

No support for the genetic hypothesis of the Black-white achievement gap using polygenic scores and tests for divergent selection

KA Bird - 2020 - osf.io
population genetic theory and avoid or remedy many of the known biases of polygenic
scores. … We can define the divergence of the means of populations (μi ) from the grand …