Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study

EC Dunn, TW Soare, Y Zhu, AJ Simpkin… - Biological …, 2019 - Elsevier
… Using a two-stage structured life course modeling approach, we tested the hypothesis that
there are sensitive periods when adversity induces greater DNAm changes. We tested this …

Sensitive periods for the effect of childhood adversity on DNA methylation: Updated results from a prospective, longitudinal study

AA Lussier, Y Zhu, BJ Smith, AJ Simpkin… - … : Global Open Science, 2023 - bpsgos.org
… We identified potential sensitive periods, largely occurring in … (5) in showing that sensitive
periods in development play an … evidence in support of sensitive periods among this new set of …

Annual research review: epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development

TL Roth, J David Sweatt - Journal of Child Psychology and …, 2011 - Wiley Online Library
sensitive periods of development influence DNA methylation patterns of several genes.
These experience-induced DNA methylation … It is clear that there are periods during postnatal …

[HTML][HTML] Do sensitive periods exist for exposure to adversity?

LJ Gabard-Durnam, KA McLaughlin - Biological psychiatry, 2019 - ncbi.nlm.nih.gov
… that a sensitive period model best fits most DNA methylationmethylation. These findings
suggest that the timing of exposure may be the most relevant consideration for DNA methylation

Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes

C Nagy, G Turecki - Epigenomics, 2012 - Taylor & Francis
DNA methylation of the exon 1 7 promoter of the Gr gene in the hippocampus Citation[18].
This not only confirmed that DNA methylation … the existence of a sensitive period for epigenetic …

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children

S Marini, KA Davis, TW Soare, Y Zhu… - …, 2020 - Elsevier
… Recently, DNA methylation (DNAm) patterns at specific CpG sites have been proposed as
a promising measure of biological aging. These DNAm-based measures are referred to as “…

Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods

JP Curley, FA Champagne - Frontiers in neuroendocrinology, 2016 - Elsevier
DNA methylation of Nr3c1 in offspring of low- compared to high-LG rat dams (Weaver et al.,
2004). Group differences in DNA methylation … This differential DNA methylation is particularly …

DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific

EW Tobi, LH Lumey, RP Talens… - Human molecular …, 2009 - academic.oup.com
Methylation was different for GNASAS ( P = 1.1 × 10 −7 ) and, in men, LEP ( P = 0.017). Our
data indicate that persistent changes in DNA methylation may be a common consequence of …

Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence

MJ Essex, W Thomas Boyce, C Hertzman… - Child …, 2013 - Wiley Online Library
Sensitive periods in brain and biological development start in the prenatal period, reach
a peak in the first few years of life and continue at a declining rate throughout childhood and …

DNA methylation, early life environment, and health outcomes

C Mitchell, LM Schneper, DA Notterman - Pediatric research, 2016 - nature.com
… This review focuses on how social and environmental signals shape DNA methylation, … of
origin inheritance, is based on the differential DNA methylation of genes present on paternal or …