L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
… -based diagnostic assays, we focused on the RBD domain of the spike protein because this … target of human antibodies (19). A major concern with using a protein domain instead of a full…
Tools to monitor SARS-CoV-2 transmission and immune responses are needed. We present a neutralization ELISA to determine the levels of Ab-mediated virus neutralization and a …
AS Iyer, FK Jones, A Nodoushani, M Kelly… - Science …, 2020 - science.org
… A detailed characterization of antibody responses is needed to determine whether antibody-… the kinetics and antibody isotype profile to the receptor binding domain (RBD) of the spike (S…
Z Cao, L Liu, L Du, C Zhang, S Jiang, T Li, Y He - Virology journal, 2010 - Springer
… -binding but also induces neutralizing antibodies. We previously identified the receptor-binding domain (RBD) of S protein as a major target of neutralizing antibodies in animal models …
… The receptor-binding domain (RBD) is immunodominant and the target of 90% of the … receptor-binding motif antigenic sites. Our results explain the immunodominance of the receptor-…
Y He, Y Zhou, S Liu, Z Kou, W Li, M Farzan… - … and biophysical research …, 2004 - Elsevier
… (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor … antibody responses in the immunized rabbits. The antibodies recognized RBD on S1 domain …
Y He, H Lu, P Siddiqui, Y Zhou… - The Journal of Immunology, 2005 - journals.aai.org
… receptor-binding domain (RBD), which mediates virus binding to angiotensin-converting enzyme 2, the functional receptor … their epitopes overlap with the receptor-binding sites in the S …
JR Byrnes, XX Zhou, I Lui, SK Elledge, JE Glasgow… - MSphere, 2020 - Am Soc Microbiol
… SARS-CoV-2 Spike protein and determine the proportion of anti-Spikeantibodies that block … ), we present natively folded viral Spike protein receptor-binding domain (RBD)-containing …
Y Wu, C Li, S Xia, X Tian, Y Kong, Z Wang, C Gu… - Cell host & …, 2020 - cell.com
… spike protein, containing the receptor-binding domain (RBD) and S1 subunit involved in receptor … We describe the development of a phage-displayed single-domainantibody library by …