Domains and functions of spike protein in Sars-Cov-2 in the context of vaccine design

X Xia - Viruses, 2021 - mdpi.com
… of structural domains and dynamics to vaccine development, and discussed reasons for the
spike protein to be frequently featured in the conspiracy theory claiming that SARS-CoV-2 is …

The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
… with SARS-CoV-1 or SARS-CoV-2 spike proteins to assess … SARS-CoV-2 spike protein
had antibodies that bound well to the RBD of SARS-CoV-2 and poorly to the RBDs of SARS-CoV-…

Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model

L Du, G Zhao, Y He, Y Guo, BJ Zheng, S Jiang, Y Zhou - Vaccine, 2007 - Elsevier
… (SARS) coronavirus (SARS-CoV) is still a priority in prevention of re-emergence of SARS. …
that the receptor-binding domain (RBD) of SARS-CoV spike (S) protein elicits highly potent …

Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine

Y He, Y Zhou, S Liu, Z Kou, W Li, M Farzan… - … and biophysical research …, 2004 - Elsevier
… fusion protein containing the RBD of SARS-CoV S protein (residues … S1 protein to ACE2
and potently neutralize SARS-CoV and SARS pseudovirus, suggesting that the RBD of S protein

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

F Li, W Li, M Farzan, SC Harrison - Science, 2005 - science.org
… S on mature SARS-CoV virions does not appear to be cleaved, and the sequence that …
The SARS-CoV spike protein RBD. (A) Domain structure of the SARS-CoV spike protein. The …

Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate

WH Chen, L Du, SM Chag, C Ma… - Human vaccines & …, 2014 - Taylor & Francis
SARS vaccine antigen consisting of the receptor-binding domain (RBD) of SARS-CoV spike
protein … responses and protection against SARS-CoV challenge in vaccinated animals. To …

Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2

S Wang, F Guo, K Liu, H Wang, S Rao, P Yang, C Jiang - Virus research, 2008 - Elsevier
… -Fc protein could bind to ACE2. We demonstrated that the RBD spike protein alone could
be internalized into SARS-CoV … of N-glycans from the RBD spike protein did not abolish this …

The spike protein of SARS-CoV—a target for vaccine and therapeutic development

L Du, Y He, Y Zhou, S Liu, BJ Zheng… - Nature Reviews …, 2009 - nature.com
… Because the SARS-CoV S protein S2 domain also contains HR1 and HR2 sequences,
we … of the SARS-CoV S protein S2 domain would also have antiviral activity against SARS-CoV. …

Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients

Z Cao, L Liu, L Du, C Zhang, S Jiang, T Li, Y He - Virology journal, 2010 - Springer
Background The spike (S) protein of SARS-CoV not only mediates receptor-binding but also
induces neutralizing antibodies. We previously identified the receptor-binding domain (RBD…

Structure of SARS-CoV-2 spike protein

J Zhang, T Xiao, Y Cai, B Chen - Current opinion in virology, 2021 - Elsevier
… This paper shows that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S
bind with similar affinities to human ACE2, and that the furin cleavage site at the boundary …