On the interactions of the receptor-binding domain of SARS-CoV-1 and SARS-CoV-2 spike proteins with monoclonal antibodies and the receptor ACE2

CC Giron, A Laaksonen, FLB da Silva - Virus research, 2020 - Elsevier
… The RBD of both SARS-CoV-1 and 2 spike proteins do bind … domain (RBD) proteins. We
also calculated free energy of interactions and shown that the S RBD proteins from both SARS

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

AS Iyer, FK Jones, A Nodoushani, M Kelly… - Science …, 2020 - science.org
… responses following infection with SARS-CoV-2 is … domain (RBD) of the spike (S) protein
of SARS-CoV-2 in a longitudinal cohort of North American patients infected with SARS-CoV-2, …

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

DJ Benton, AG Wrobel, P Xu, C Roustan, SR Martin… - Nature, 2020 - nature.com
… the SARS-CoV-2 spike protein and its receptor, we mixed the ectodomains of furin-cleaved
spike … Similar changes in the domain orientation are observed in the recent structure of the …

Identifying distinct structural features of the SARS-CoV-2 spike protein fusion domain essential for membrane interaction

D Birtles, J Lee - Biochemistry, 2021 - ACS Publications
… The SARS-CoV-2 spike protein is the primary antigenic determinant of the virus and has …
The fusion domain (FD) of viral glycoproteins is well established as facilitating the initiation of …

Molecular biology of the SARsCoV‐2 spike protein: A review of current knowledge

C Zhu, G He, Q Yin, L Zeng, X Ye… - Journal of medical …, 2021 - Wiley Online Library
… A breakdown of the functional domains of the SARS-CoV-2 S, based on SARS-CoV S …
domains, the spike protein plays a pivotal role in the biology and pathogenesis of SARS-CoV

A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2

AW Struck, M Axmann, S Pfefferle, C Drosten, B Meyer - Antiviral research, 2012 - Elsevier
SARS coronavirus (SARS-CoV) … virus Sindbis shows no reduction in infectivity. Peptide 438
YKYRYL 443 is part of the receptor-binding domain (RBD) of the spike protein of SARS-CoV. …

[PDF][PDF] Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry

E Qing, P Li, L Cooper, S Schulz, HM Jäck, L Rong… - Cell Reports, 2022 - cell.com
… , entry-facilitating spike proteins. To recognize the significance of … spike protein changes,
we compare variant SARS-CoV-2 virus particles in several assays reflecting authentic virus

Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination

A Sternberg, C Naujokat - Life sciences, 2020 - Elsevier
… The structure of the complex was determined by molecular replacements using the RBD of
SARS-CoV S and domains of ACE2 as search models, and was refined to a resolution of 2.45 …

Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits

S Ravichandran, EM Coyle, L Klenow, J Tang… - Science translational …, 2020 - science.org
… rabbits with various SARS-CoV-2 spike protein antigens: S … and transmembrane domains
(CT-TM), the S1 domain (amino … SARS-CoV-2 antigens to spike protein and domains from …

[HTML][HTML] Structural comparison of the SARS CoV 2 spike protein relative to other human-infecting coronaviruses

ME Cueno, K Imai - Frontiers in medicine, 2021 - frontiersin.org
domains in viral pathogenicity (9, 14, 27). To visualize and compare the CoV spike proteins,
each human-infecting CoV spikedomains located in the globular S1 subunit of CoV spike