[HTML][HTML] Receptor-binding domain of SARS-CoV-2 spike protein efficiently inhibits SARS-CoV-2 infection and attachment to mouse lung

HJ Shin, KB Ku, HS Kim, HW Moon… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
… The receptor-binding domains (RBDs) in the spike protein of SARS-CoV and MERS-CoV
have … The signal peptide in the spike protein of SARS-CoV-2 was also identified to facilitate …

[HTML][HTML] Flexible, functional, and familiar: characteristics of SARS-CoV-2 spike protein evolution

DS Saputri, S Li, FJ Van Eerden, J Rozewicki… - Frontiers in …, 2020 - frontiersin.org
… evenly across the S protein but were concentrated in two domains: the N-terminal … in the
SARS-CoV-2 S protein, we carried out molecular dynamic simulations of the S protein in the …

Distinct conformational states of SARS-CoV-2 spike protein

Y Cai, J Zhang, T Xiao, H Peng, SM Sterling… - Science, 2020 - science.org
protein for CoV is its spike (S) protein that decorates the virion surface as an extensive crown
(hence, “corona”). The protein … Binding through the receptor-binding domain (RBD) in S1 to …

[HTML][HTML] Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2

R Yan, Y Zhang, Y Li, F Ye, Y Guo, L Xia, X Zhong… - Cell research, 2021 - nature.com
… S1 consists of the N-terminal domain (NTD), the RBD, … the activation of the S protein of
SARS-CoV-2 represents a … of trimeric extracellular domain of the S protein (hereinafter referred to …

[HTML][HTML] Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms

A Ali, R Vijayan - Scientific reports, 2020 - nature.com
… were performed to better understand the structural stability and interfacial interactions
between the receptor binding domain of the spike (S) protein of SARS-CoV-2 and SARS-…

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARSCoV‐2

Z Liu, X Xiao, X Wei, J Li, J Yang, H Tan… - Journal of medical …, 2020 - Wiley Online Library
… In this study, we used systematic comparison and analysis to predict the interaction between
the receptor-binding domain (RBD) of coronavirus spike protein and the host receptor, …

[HTML][HTML] N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains

A Klinakis, Z Cournia, T Rampias - Computational and Structural …, 2021 - Elsevier
domain of the SARS-CoV-2 spike protein have evolutionary diverged in comparison to other
beta-coronaviruses and particularly SARS-CoV… of mutations, driving SARS-CoV-2 evolution. …

Inactivated SARS-CoV vaccine elicits high titers of spike protein-specific antibodies that block receptor binding and virus entry

Y He, Y Zhou, P Siddiqui, S Jiang - Biochemical and biophysical research …, 2004 - Elsevier
… inactivated by β-propiolactone elicited high titers of antibodies in the immunized mice and
rabbits that recognize the spike (S) protein, especially the receptor-binding domain (RBD) in …

Rapid development of SARS-CoV-2 spike protein receptor-binding domain self-assembled nanoparticle vaccine candidates

YF Kang, C Sun, Z Zhuang, RY Yuan, Q Zheng, JP Li… - ACS …, 2021 - ACS Publications
… In this study, we designed SARS-CoV-2 vaccine candidates by linking the spike protein RBD
to a nanoparticle via a covalent ligation strategy. By fusing SpyTag to the C-terminus of RBD…

[PDF][PDF] Identification of human single-domain antibodies against SARS-CoV-2

Y Wu, C Li, S Xia, X Tian, Y Kong, Z Wang, C Gu… - Cell host & …, 2020 - cell.com
… antibodies and apply this methodology to identify SARS-CoV-2-specific … single-domain
antibodies target diverse epitopes within the SARS-CoV-2 spike protein receptor binding domain (…