Outpatient treatment of SARS-CoV-2 infection to prevent COVID-19 progression

MS Cohen, DA Wohl, WA Fischer, DJ Smith… - Clinical Infectious …, 2021 - cdr.lib.unc.edu
… for hospitalized patients in the US (22), and supported a recent trial demonstrating the
antiviral activity molnupiravir in volunteers with mild symptomatic COVID-19 (23), and the FDA …

Use of molnupiravir in patients who developed SARS-CoV2-Infection during hospitalization

GT Dizman, Y Çakır, G Korubük, G Metan, S Ünal - Acta Medica, 2023 - actamedica.org
… might encourage the use of molnupiravir in these patients despite the remaining controversy
in … analyzed 45 patients who were hospitalized for other reasons and used molnupiravir for …

[PDF][PDF] Efficacy and safety of Molnupiravir in COVID‑19 patients: a systematic

KR Mali, M Eerike, GM Raj, D Bisoi, R Priyadarshini… - academia.edu
… (n= 130) to find out the safety and dosing range of Molnupiravir. It was found safe and well
… which was a Phase Ib/IIa dose escalation study conducted in eighteen COVID-19 patients. …

[HTML][HTML] RdRp inhibitors and COVID-19: Is molnupiravir a good option?

SMR Hashemian, MH Pourhanifeh, MR Hamblin… - Biomedicine & …, 2022 - Elsevier
… was reached, the dose escalation was discontinued [121]. … Molnupiravir was well tolerated
at all three doses without any … of 4 of patients receiving 300, 600 or 800 mg of molnupiravir, …

[HTML][HTML] Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis

T Pitre, R Van Alstine, G Chick, G Leung, D Mikhail… - Cmaj, 2022 - Can Med Assoc
patients with nonsevere COVID-19. Nirmatrelvir–ritonavir is probably more effective than
molnupiravir … Most trials were conducted with unvaccinated patients, before the emergence of …

[PDF][PDF] Safety monitoring of molnupiravir for treatment of mild to moderate COVID-19 infection in low and middle-income countries using cohort event monitoring: a …

World Health Organization - 2022 - apps.who.int
… be recruited among patients who are prescribed molnupiravir for treatment of … dose
and safety of molnupiravir in patients with early SARS-CoV2: a Phase I, open-label, dose-escalating

The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19)

P Pagliano, C Sellitto, T Ascione… - Expert Opinion on …, 2022 - Taylor & Francis
… Similar data were reported in a dose-escalating study, where doses ranging from 300 to 800
Molnupiravir could be the drug of choice for patients with COVID-19 reporting comorbidities …

A path from synthesis to emergency use authorization of molnupiravir as a COVID-19 therapy

N Sakander, A Ahmed, M Bhardwaj, D Kumari… - Bioorganic …, 2024 - Elsevier
… In this investigation, the primary endpoint was the percentage of patients who were hospitalized
or died by day-29, and the treatment impact estimates for this endpoint were lower in all-…

Innovative randomized phase I study and dosing regimen selection to accelerate and inform pivotal COVID‐19 trial of nirmatrelvir

RSP Singh, SS Toussi, F Hackman… - Clinical …, 2022 - Wiley Online Library
… The nucleoside inhibitor molnupiravir received EUA shortly … was built during the dose
escalation based on the preliminary … Dosing for > 5 days in symptomatic patients was predicted to …

Cost-effectiveness of oral nirmatrelvir/ritonavir in patients at high risk for progression to severe COVID-19 in the United States

J Carlson, V Foos, A Kasle, T Mugwagwa, F Draica… - Value in Health, 2024 - Elsevier
… duration that patients experience symptom day quality of life decrements. For patients who
… parameters were applied to estimate the risk of escalation of care (general ward, ICU, and …