Independent drug action in combination therapy: implications for precision oncology

D Plana, AC Palmer, PK Sorger - Cancer discovery, 2022 - AACR
… can be highly effective in patient populations in the absence of drug interaction (either … drug
action. We review evidence from trials run by the founders of combination therapy, including …

Drug combination therapy increases successful drug repositioning

W Sun, PE Sanderson, W Zheng - Drug discovery today, 2016 - Elsevier
… concentrations of individual drugs … have found that drug combination therapy using two-to-three
compounds with different mechanisms of action can overcome the above described drug

Defining principles of combination drug mechanisms of action

JR Pritchard, PM Bruno, LA Gilbert… - Proceedings of the …, 2013 - National Acad Sciences
… Thus, not only could we extend this averaging hypothesis to a distinct cell type, but the
analysis of combination therapy in this model allowed us to examine the averaging model …

[HTML][HTML] Combination therapy in combating cancer

RB Mokhtari, TS Homayouni, N Baluch… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… Because one of the drugs used in combination therapy is already FDA-approved, overall
costs of combination therapy research are reduced. This increases cost efficiency of therapy, …

Systems biology and combination therapy in the quest for clinical efficacy

JB Fitzgerald, B Schoeberl, UB Nielsen… - Nature chemical …, 2006 - nature.com
combination therapies, drugs act in a nonexclusive manner on one or more targets, arguing
for use of Bliss independence. However, when drugs … ) 29 , the combination may act …

Effectiveness of antiepileptic drug combination therapy for partial-onset seizures based on mechanisms of action

JM Margolis, BC Chu, ZJ Wang, R Copher… - JAMA …, 2014 - jamanetwork.com
… of different-MOA vs same-MOA combinations in AED therapy, to our knowledge, there are …
combination therapies for treatment of POS are more effective than non-MOA–based therapies

Artificial intelligence in drug combination therapy

IF Tsigelny - Briefings in bioinformatics, 2019 - academic.oup.com
therapy, a physician often meets a patient having a genomic profile including more than five
molecular aberrations. Drug combination therapy … the synergism of drugs was published in …

DCDB: drug combination database

Y Liu, B Hu, C Fu, X Chen - Bioinformatics, 2010 - academic.oup.com
… Summary: Rapid advances in pharmaceutical sciences have brought ever-increasing
interests in combined therapies for better clinical efficacy and safety, especially in cases of …

Combination drugs, an emerging option for antibacterial therapy

G Cottarel, J Wierzbowski - Trends in biotechnology, 2007 - cell.com
… This article explores the potential for combination drug therapies to treat bacterial infections.
We believe that combination therapies have a real and broad potential to address antibiotic …

Combination therapy in epilepsy: when and what to use

P Kwan, MJ Brodie - Drugs, 2006 - Springer
… This study provided evidence that dose-related toxicity associated with combination therapy
could be reduced by paying attention to drug load. However, the study did not to identify any …