… concentrations of individual drugs … have found that drugcombinationtherapy using two-to-three compounds with different mechanisms of action can overcome the above described drug …
… Thus, not only could we extend this averaging hypothesis to a distinct cell type, but the analysis of combinationtherapy in this model allowed us to examine the averaging model …
… Because one of the drugs used in combinationtherapy is already FDA-approved, overall costs of combinationtherapy research are reduced. This increases cost efficiency of therapy, …
… combinationtherapies, drugs act in a nonexclusive manner on one or more targets, arguing for use of Bliss independence. However, when drugs … ) 29 , the combination may act …
JM Margolis, BC Chu, ZJ Wang, R Copher… - JAMA …, 2014 - jamanetwork.com
… of different-MOA vs same-MOA combinations in AED therapy, to our knowledge, there are … combinationtherapies for treatment of POS are more effective than non-MOA–based therapies…
IF Tsigelny - Briefings in bioinformatics, 2019 - academic.oup.com
… therapy, a physician often meets a patient having a genomic profile including more than five molecular aberrations. Drugcombinationtherapy … the synergism of drugs was published in …
Y Liu, B Hu, C Fu, X Chen - Bioinformatics, 2010 - academic.oup.com
… Summary: Rapid advances in pharmaceutical sciences have brought ever-increasing interests in combinedtherapies for better clinical efficacy and safety, especially in cases of …
G Cottarel, J Wierzbowski - Trends in biotechnology, 2007 - cell.com
… This article explores the potential for combinationdrugtherapies to treat bacterial infections. We believe that combinationtherapies have a real and broad potential to address antibiotic …
… This study provided evidence that dose-related toxicity associated with combinationtherapy could be reduced by paying attention to drug load. However, the study did not to identify any …