… clearance. The objective of this study was to extend population models to predict systemic
and oral drug clearance … with mechanistic IVIVE within the Simcyp Simulator, he clearance of …

… of drug clearance. This review summarizes the discussion topics at the 2013 AAPS
symposium on “Dealing with the complex drug-drug interactions: towards mechanistic models”. …

… Reasons for poor clearance prediction success will be … of drug clearance. Particular
emphasis will be on extrahepatic metabolism, consideration of transporter contribution to drug …

… to develop a comprehensive mechanistic (whole-body PBPK) model of repaglinide, utilizing
… intrinsic clearance values obtained from in vitro studies. The mechanistic model was used to …

… uptake clearance; and … clearance likely the predominant clearance mechanism. Validation
of this framework with more than 300 drugs for which the predominant clearance mechanism …

… will only be dose- and concentration-independent at unbound concentrations that are
significantly below the K m for the clearance mechanism. High dose studies (such as those used in …

… and active secretion in renal drug elimination. Finally, … of drugs in renal tubular cells
necessitates improved physiological and mechanistic modeling of drug distribution and clearance in …

… between uptake clearances obtained from full kinetic experiments in human hepatocytes
and the value estimated on the basis of data generated at 1 μM only using mechanistic model. …

… and mechanistic models for the prediction of human IV clearance … The corresponding
mechanistic model with full in silico … the models were confirmed with the prediction of 16 Pfizer …

… This study indicated that the mechanistic model allowed for … PK profiles and plasma
clearances, using PBPK modeling. … drugs are based on optimized compartmental models. In this …