… This article describes the extensive investigation of the published literature on a large
number of drug combinations from interaction and network perspectives, which reveals general …

… identification of synergistic drug combinations at the molecular level. The network target-…
Thus, from the network target perspective, we can gain a comprehensive understanding of …

… find that FDA-approved drug combinations have lower s AB compared to random drug
pairs and the separation-… We find that from a network perspective, all possible drug–drug–disease …

… Drug combinations that target multiple pathways can also delay the … drug combinations
may also allow for the reduction of dose levels of individual drugs used in the combination and …

… perspective on how large-scale interaction networks are utilized at different steps of the modern
drug … as drug combinations, synergy as well drug repurposing. Construction of accurate …

… In this review, we have explored mathematical methods that model combination therapies
from various perspectives. We investigated methods that predict the synergism and …

… Results: We report a systems pharmacology framework to predict drug combinations (…
and adverse effects of drug combinations. First, a Bayesian network integrating with a similarity …

… drug-perturbated transcription profiles; 2) Network-based assessment: quantifying the
network-based relationship between drug … the predicted drug pairs from a network perspective; …

… network perspective. Currently, some systems biology approaches have been applied in
drug … This study found that drug combination effects largely depend on network topology, and …

… [66] considered drug combinations in the perspective of genetic interaction network and
associated human pathways. They found that drug combinations alter functionally correlated …