Recent progress in the drug development targeting SARS-CoV-2 main protease as treatment for COVID-19

W Cui, K Yang, H Yang - Frontiers in molecular biosciences, 2020 - frontiersin.org
… efforts to discover new drugs that efficiently treat COVID-19 are … SARS-CoV-2 and summarize
the recent important progresses in its drugs targeting, which may facilitate the development

Drug development and medicinal chemistry efforts toward SARScoronavirus and Covid‐19 therapeutics

AK Ghosh, M Brindisi, D Shahabi… - …, 2020 - Wiley Online Library
drugs will likely be essential to tackle this pandemic. In this review, we highlight the potential
drug development … chemistry efforts toward the evolution of drug-like small molecules. …

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2)-an update on the status

TM Abd El-Aziz, JD Stockand - Infection, Genetics and evolution, 2020 - Elsevier
… Furthermore, anti-virus vaccine development is also significant to … -nCoV life cycle are
needed. These likely will accelerate the development of drugs and/or vaccine against SARS-CoV-2…

Recent drug development and medicinal chemistry approaches for the treatment of SARSCoV‐2 infection and COVID‐19

AK Ghosh, JL Mishevich, A Mesecar… - ChemMedChem, 2022 - Wiley Online Library
developing concepts and strategies to block SARS-CoV-1 … development of mechanism-based
drugs against SARS-CoV-… here recent developments and approaches to SARS-CoV-2 …

[HTML][HTML] Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Y Huang, C Yang, X Xu, W Xu, S Liu - Acta Pharmacologica Sinica, 2020 - nature.com
… in the structure, function and development of antivirus drugs targeting the S protein. … of
the SARS-CoV-2 S protein is of great significance for subsequent new drug development and …

Recent advances in pathophysiology, drug development and future perspectives of SARS-CoV-2

DD Singh, I Han, EH Choi, DK Yadav - … in cell and developmental …, 2020 - frontiersin.org
… At present, we do not have any drugs approved for SARS-CoV-2 by … SARS-CoV-2 in terms
of pathophysiology, epidemiology, clinical management, drug discovery, vaccine development

Progress in computational approach to drug development against SARS

KC Chou, DQ Wei, QS Du, S Sirois… - Current Medicinal …, 2006 - ingentaconnect.com
… proteinase, the so-called SARS coronavirus main proteinase (SARS CoV Mpro), is a key …
target for developing drugs against SARS. To conduct the rational, or structure-based, drug de…

Understanding individual SARS-CoV-2 proteins for targeted drug development against COVID-19

J van de Leemput, Z Han - Molecular and cellular biology, 2021 - Taylor & Francis
… We have grouped the SARS-CoV-… SARS-CoV-2 proteins and summarizes current knowledge
on how these proteins promote virus replication and disrupt host systems, as well as drugs

[HTML][HTML] Drug discovery strategies for SARS-CoV-2

ZA Shyr, K Gorshkov, CZ Chen, W Zheng - Journal of Pharmacology and …, 2020 - ASPET
… of developing vaccines and therapeutics against SARS-CoV-2. This review highlights the
anti–SARS-CoV-2 drug targets and therapeutic development … COVID-19 drug development, but …

Potential of Marine Terpenoids against SARS-CoV-2: An In Silico Drug Development Approach

A Sahoo, S Fuloria, SS Swain, SK Panda, M Sekar… - Biomedicines, 2021 - mdpi.com
… suggest that the SARS-CoV-2 is a genetically modified strain of the CoV family and the
mutated/modified genetic information may be helpful for drug development against SARS-CoV-2. …