… , and species differences of hepatic transporters had been described. … hepatic transporters
on drug distribution, metabolism, and excretion, which collectively refer to as drug disposition…

… transporter proteins in relation to the drug disposition process, with particular emphasis on
clinical implications of transporters to drug-drug … of certain hepatic transporters in initiating the …

… hepatic transporters in pharmacokinetics and drug‐drug interactions (DDIs). Special emphasis
is placed on transporters … 1B3 emerged as important hepatic drug uptake pathways, sites …

… Although some changes in drug disposition profiles were observed, data appear to be
inconclusive. Results might also be confounded by probe substrate selection, racial background …

… , transporters from the ABC family mediate efflux of drugs and metabolites … hepatic transporters
may be inhibited by drugs or their metabolites, while they are not transporting these drugs …

… presence of drugs that inhibit its ability to serve as a transporter and by … The impact of P-glycoprotein
on drug disposition is … and inhibitors of hepatic transporters for drugs that undergo …

… Recent times have witnessed a significant progress in our molecular understanding of role
of drug transporters in disease and drug disposition/ADMET. Emphasis on such studies is …

… of transporters and metabolic enzymes in hepatic drug processing. Enalapril, a drug whose
… are inter-related in the estimation of the hepatic and metabolic, and excretion clearances. …

… In this review theoretical concepts behind transporter-enzyme interplay in the hepatic
disposition of drugs are reviewed, and the utility of integrated mechanistic models for predicting …

… Drug transporters and regulatory guidance Given the established role of transporters in
drug disposition and pharmacokinetic drug-drug interactions, both the Food and Drug …