… processes that govern drug disposition and response. Most … of drug-metabolizing enzymes
to the drug disposition process. … transporters, also play critical roles in the overall disposition …

… concepts behind transporter-enzyme interplay in the hepatic disposition of drugs are reviewed…
Further, the state of the mechanistic understanding of the role of transporters and enzymes …

… enzymes, kidney function, and transporters. Recent research on human transporters has
greatly advanced our understanding of their diversity and importance in drug disposition…

… between cytochrome P450 enzymes (CYPs) and efflux transporters have been …
transporters, CYPs–uptake transporters-efflux transporters, and phase II metabolic enzymes–transporters …

… -dependent, transporter-mediated drug-drug interactions will … on the impact of transporters
on drug disposition is included in … the drug metabolism–drug transport interplay for drug-drug …

… classification of drug transporters, their roles in drug disposal/drug response… drug transporters
can be regarded as completing the phase I or II enzyme-based detoxification system; drug …

… of transporters and metabolic enzymes in hepatic drug processing. Enalapril, a … transporters
mediate biliary excretion and basolateral efflux, transporters compete with enzymes for drug …

… the drug-related properties and transporter-mediated disposition. The approach allows
prospective prediction of transporter both … enzymes and transporters. Also, the rate-limiting step of …

… The role of P-gp and CYP3A in modulating hepatobiliary drug disposition was examined
ex situ using the isolated perfused rat liver system described above. The transport and …

… about in vivo transporter functions in drug disposition and distribution in … drug transporters
on clinically relevant drug disposition and DDIs is equal to that of drug-metabolizing enzymes. …