Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes

T Glauser, E Ben‐Menachem, B Bourgeois… - …, 2013 - Wiley Online Library
… for efficacy/effectiveness, and (3) the relationship table between clinical trial ratings, level of
evidence, … to reinforce that this review of efficacy/evidence for specific seizure types does not …

Systematic review on the therapeutic options for COVID-19: clinical evidence of drug efficacy and implications

AR Abubakar, IH Sani, B Godman… - Infection and drug …, 2020 - Taylor & Francis
… A systematic review of published clinical … no clinical evidence of efficacy in randomized
controlled clinical trials (RCT). However, retrospective observational studies reported the efficacy

ILAE treatment guidelines: evidence‐based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes

T Glauser, E Ben‐Menachem, B Bourgeois… - …, 2006 - Wiley Online Library
clinical trial (RCT) evidence of efficacy or tolerability in patients with epilepsy. The clinical
the beginning of more formalized AED efficacy and tolerability assessment. The recent …

The genetics of drug efficacy: opportunities and challenges

MR Nelson, T Johnson, L Warren, AR Hughes… - Nature Reviews …, 2016 - nature.com
… We have provided evidence that only a minority of truly efficacious drugs are likely to have
clinically meaningful genetic predictors of efficacy. However, even when such predictors do …

The emergence of loss of efficacy during antidepressant drug treatment for major depressive disorder: an integrative review of evidence, mechanisms, and clinical …

M Fornaro, A Anastasia, S Novello, A Fusco… - Pharmacological …, 2019 - Elsevier
… with antidepressant drugs is a complex clinical phenomenon referred to as … evidence
from both pre-clinical and clinical studies, focusing on putative mechanisms as well as clinical

Overview of the clinical efficacy of investigational anticancer drugs

P Nygren, R Larsson - Journal of internal medicine, 2003 - Wiley Online Library
… The purpose of this overview was to make a broad inventory of investigational drugs for
medicinal cancer treatment and, specifically, to indicate the evidence of clinical efficacy. …

Neurostimulation for drug-resistant epilepsy: a systematic review of clinical evidence for efficacy, safety, contraindications and predictors for response

P Boon, E De Cock, A Mertens… - Current opinion in …, 2018 - journals.lww.com
… -to-moderate quality evidence that VNS is well tolerated in both children and adults with drug-…
quality evidence for the effectiveness of VNS in adults with drug-resistant partial epilepsies. …

The evasive nature of drug efficacy: implications for drug discovery

S Galandrin, G Oligny-Longpré, M Bouvier - Trends in pharmacological …, 2007 - cell.com
… The efficacy of a drug is generally determined by the drug's … -occupancy theory, the efficacy
is considered an intrinsic … efficacy at serotonin type 2A and 2C receptors: evidence for …

Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease)

AD Roses, AM Saunders, Y Huang, J Strum… - The …, 2007 - nature.com
… If these AE-susceptible patients could be identified before receiving the drug, medical care
would be more evidence based and accurate. The increased risks of untreated disease in …

A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies

AA Izzo, S Hoon‐Kim, R Radhakrishnan… - Phytotherapy …, 2016 - Wiley Online Library
… The Clinical Efficacy of Herbal Remedies Similar to conventional drugs, clinical evidence
on herbal medicine comes primarily from case reports, uncontrolled clinical trials and …