Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors

D Williams, J Feely - Clinical pharmacokinetics, 2002 - Springer
interactions. Drug interactions involving the statins may have either a pharmacodynamic or
pharmacokinetic basis, or both. As these drugs are highly extracted by the liver, displacement …

… and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drugdrug interactions and interindividual differences …

Y Shitara, Y Sugiyama - Pharmacology & therapeutics, 2006 - Elsevier
… This review will summarize the mechanism of drugdrug interactions between statins
and other drugs, using comparisons of the characteristics of statins, their physicochemical …

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins)

M Igel, T Sudhop, K Von Bergmann - European journal of clinical …, 2001 - Springer
… pharmacokinetic properties of statins and to emphasise their clinically important drug
interactions. … lism and drug interactions of the 3-hydroxy-3-methylglutarylCoA reductase inhibitors …

Drugdrug interactions between HMG-CoA reductase inhibitors (statins) and antiviral protease inhibitors

B Chauvin, S Drouot, A Barrail-Tran… - Clinical pharmacokinetics, 2013 - Springer
… PIs to undergo drugdrug interactions [30]. … drugdrug interactions between statins and
PIs currently approved in the treatment of HIV or HCV infection. We will also discuss interactions

HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles

SL Beaird - Journal of the American Pharmaceutical Association …, 2000 - Elsevier
… significant drug interactions and subsequent adverse drug reactions. CYP3A4 is one of the
major isoenzymes of the CYP450 group. Drug-drug interactions can occur when drugs that …

Prevalence of potentially severe drug-drug interactions in ambulatory patients with dyslipidaemia receiving HMG-CoA reductase inhibitor therapy

AE Rätz Bravo, L Tchambaz, A Krähenbühl-Melcher… - Drug safety, 2005 - Springer
… practitioners checked the medication list for drug-drug interactions before transmitting it.
The true prevalence of drug-drug interactions may therefore be higher than found in our study. …

Cytochrome P450 drug interactions within the HMG-CoA reductase inhibitor class: are they clinically relevant?

J Martin, H Krum - Drug safety, 2003 - Springer
drug interactions within the HMG-CoA reductase inhibitor class. These interactions can result
in markedly increased or decreased plasma concentrations of some drugs within this class. …

HMG-CoA reductase inhibitors (statins) and their drug interactions involving CYP enzymes, P-glycoprotein and OATP transporters-an overview

R Balasubramanian, NMP Maideen - Current drug metabolism, 2021 - ingentaconnect.com
… in polypharmacy and the risk of drug interaction is increased with the … interaction between
statins and other drugs and to provide recommendations on how to deal with such interactions

Drug interactions of lipid-altering drugs

HE Bays, CA Dujovne - Drug Safety, 1998 - Springer
… Due to potential such drug interactions such as this mibefradil has been withdrawn.[8] In …
drug interactions prior to prescribing HMG-CoA reductase inhibitors, to changing HMGCoA

Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors

WR Garnett - American Journal of Health System Pharmacy, 1995 - academic.oup.com
… profiles of HMG-CoA reductase inhibitors and explores the specif ic drug interactions that
have … characteristics of the four HMGCoA reductase inhibitors, each agent displays a unique …