… of OATP1B1, OATP1B3, the multidrug resistance-associated protein (MRP) 2, and MRP3. No
substrate interaction was shown for other prominent drug … carrier (SLC) family, while in vitro …

… OATP) transporter family are involved in drug absorption and disposition, and therefore
drug–drug and drug–food interactions … , as well as the resulting interactions, is required. However…

… The importance of this transporter family in drug disposition … From the drug interaction point
of view, considering the high … interactions of these flavonoids with drugs that are OATP1B1 …

… and Drug Administration (FDA) draft guidance on pharmacokinetic drug-drug interactions
(… -transporting polypeptide transporters (OATPs), ABC drug transporter ABCB1 or Pglycoprotein …

… drug interactions. These findings with grapefruit and other fruit juices continue to enhance our
understanding of the complex nature of food–drug interactions… the OATP transporter family. …

… Subsequently, many human and rodent OATP/Oatp transporter molecules have been
isolated and the OATP/Oatp family currently consists of more than 40 members in humans, rats, …

… exposure (the former increasing and the latter decreasing drug exposure), which complicates
the interpretation as well as prediction of OATP drug interactions. The OATP family has a …

… on their DrugBank (46) drug names. Our drug interaction hypothesis was whether CQ plus
… whether other OATP transporters, including the closely related family member OATP1B3, …

… Organic anion transporting polypeptides (OATPs) are transmembrane transport proteins …
Of the 11 human OATP family members, OATP1A2 and OATP2B1 have been reported to be …

… 1B3, only transcripts of OATP1B1 and 1B3 were expressed in … of induction of OATP1B3 was
greater than that of OATP1B1. … family is important in metabolizing a wide variety of drugs, we …