… concluded that although there are differences in CYP2B6 protein expression and function, …
catalytic activity and hepatic expression of CYP2B6 functional protein, increased IFA plasma …

… specificity of ligands and DNA response elements for individual receptors, as well as the
manner in which they interact to affect gene expression in a synergistic or antagonistic fashion. …

… In this study, the influence of CYP1B1 on the cytotoxic profile of several anticancer drugs
commonly in clinical practice was evaluated in a Chinese hamster ovary cell line expressing …

… in terms of drug–drug interactions and drug toxicity. After a short description of the efflux protein,
… Expression of transport proteins in the heart can be an important factor that could modify …

… that are known to inhibit the hepatic metabolism of the drug under … drug-drug interactions
via inhibitory mechanisms and have tried to predict in vivo interactions from in vitro data on drug …

… While drug interaction with a set of targets seems to be beneficial for efficacy in … a drug's
targets by considering gene expression following treatment in the view of a functional protein …

… and protein expression were not yet currently available. Thus, the mechanism by which
cirrhosis may alter AhR-mediated induction remain to be elucidated. Moreover, both animal and …

… At 10 μM, ritonavir and nelfinavir suppressed CYP3A4 activity but induced its transcripts
and protein expression (19- and 12- and 12- and 6-fold, respectively; a >2-fold change over …

… Recently, Huang et al. developed a target-center system for each drug, which consists of
drug targets and their first neighbors in the PPI network and human tissue gene expression [18]. …

… down regulation of hepatic CYP has been suggested to be a result of the effect of cytokines
produced by the nonparenchymal cells on the CYP gene expression in the hepatocytes [27]. …