… , and clarithromycin combined with midazolam as the substrate. Bosentan (6), repaglinide
(7… substrates of hepatic OATPs. Clarithromycin was reported not to be a substrate for OATP1B1…

… Apparent K m values for the OATP1B1-mediated transport of [ 3 H] substrates were determined
prior to their use as probes in inhibition studies, and ranged from 0.6 to 29 μM for statins. …

… empty vector was devoid of OATP1B1 expression and is named … a tool to assess OATP1B1
substrates and inhibition was conducted … of substrates and inhibitors of OATP1B1 in the drug-…

… of organic anion transporting polypeptide (OATP) 1B1 and 1B3, with … BOC was a substrate
for Pgp and BCRP but not for OATP1B1… OATP1B1 in vitro inhibition by several known OATP …

… capacity was determined with atorvastatin as the victim drug. There were clear differences
in OATP inhibition pattern when using atorvastatin as substrate instead of prototypical model …

… /1B3-mediated DDIs in order to avoid unwanted adverse effects of drugs that are OATP
substrates due to their altered pharmacokinetics. Growing evidences suggest that the transport …

… OATP1B1. Therefore, it was of value to continue to search for and identify a suitable substrate
for OATP1B1 … a potential candidate for use as an OATP1B1 substrate in vitro. There are a …

… inhibition of drug transporters. We propose a cocktail consisting of the following substrates to
… These results clearly suggest that furosemide is a substrate of OAT1, OAT3, OATP1B1, and …

… of OATP substrates is often hepatic uptake. Because of their broad substrate specificities,
once the functions of OATP1B1 … of special occasions such as drug–drug interactions (DDI) and …

… exposure (the former increasing and the latter decreasing drug exposure), which … prediction
of OATP drug interactions. The OATP family has a broad spectrum of substrates ranging from …