… them sensitive index substrates of these enzymes, but both are also fairly sensitive substrates
of OATP1B1/1B3.16 The usefulness of both these drugs as index substrates has been …

… and OATP1B3 in nonhuman primates and humans) [20], resulting in species differences
in the uptake activity and substrate specificity of OATP substrates [21]. However, animal PK …

… whether NSAIDs were also substrates for OATP1B1 and OATP1B3 and … substrate
spectrum, OATP1B1 and OATP1B3 are involved in transporter-mediated drug-drug interactions…

… on interactions between clinically used OATP substrates and … potential interaction between
clinically used OATP substrates … OATPs, proposed mechanism of fruit juice–drug interactions, …

… The estimation of the role of a single transporter in drug–drug interaction may be
challenging, because, for example, many OATP1B1 substrates are also substrates of other drug …

… Since the substrate specificities of OATP1B1, 1B3, and 2B1 are broad and overlapping, the
… is of concern when assessing transporter-mediated drug–drug interactions (DDIs) or genetic …

… QID) in plasma, with no effect on their renal elimination in line with the in vitro results that
probenecid is not a potent inhibitor of OATP/MRP and that CPPs are not a substrate of OATs. …

… Figure 6 Predicted and observed area under the concentration-time curve ratios (AUCRs)
in studies of 54 drug-drug interactions that involve 12 OATP substrates (modified from …

… -1B1 and/or -1B3 inhibitors) along with other hepatic OATP substrates (paclitaxel, … of
OATP substrates. Inhibition of hepatic uptake of OATP substrates by coadministration of OATP …

… in regulating OATP activity. With respect to drug development, the complexity of OATP
regulation requires in vitro measurements of more than one OATP substrate and metabolite […