… drug interaction profile of asunaprevir from preclinical development to the present. 2 Preclinical
… Compared with findings in matched controls with normal hepatic function, there was no …

… Drug interactions (DIs) may result in adverse drug events that could be prevented, but in …
transferable to clinical practice. The majority of studies date from preclinical or premarketing …

… In recent years, an increasing number of clinical drug–drug interactions (DDIs) have been
… , only a few of these DDI results were reflected in drug labels. This review aims to provide a …

… preclinical studies to assess potential drug-drug interactions in humans concerning clinical
applications of drugs. … The significance of this finding is that in the case of polipharmacy, used …

… a detailed analysis of the preclinical and clinical enzyme- and … main mechanistic findings
and discussing their clinical relevance. … Drug Interaction Database (DIDB) drug interactions, …

… on drug interactions during preclinical and clinical development… a rational in vivo drug-drug
interaction programme; performing … However, experimental findings and clinical experience …

… Even though preclinical findings did not suggest major interaction between PSL and VPA,
a … , a clinical study was performed to assess the potential for clinically relevant interaction …

… may play significant roles in drug-drug interactions. … The mechanistic findings may aid
the definition of the clinical significance of the … Subgroup analysis and drug interactions, …

… sant/antiepileptic drugs with novel (ideally more selective) targets therefore still remains in
clinical and preclinical research. Experimental and clinical findings support a crucial role for …

… drug–drug interaction studies in preclinical models; (ii) to provide a general framework and
strategy from a preclinical … Hence based on the in vitro evidence of CYP3A inhibition, an in …