… recommendations on a broad range of in vitro and in vivo studies to evaluate drug–drug
interaction (… This paper aims to provide an overview of these new recommendations and an in-…

… potential drug interactions. 4. Evaluate the strengths and weaknesses of available drug
interaction resources. … The authors recommended that clinicians check more than one drug …

… However, EMEA recommends using unbound concentration for both the K i … Recommended
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… CYP2D6, genotype-based recommendations to consider therapeutic drug monitoring or
dose reduction are implicit on the basis of drug interaction recommendations). Otherwise, PGx …

… evaluating patients for potential drug interactions during therapy 1. Drug−drug interactions
(DDIs) occur when a patient's pharmacological or clinical response to the drug is modified by …

… Applying the categorization recommended by the FDA, any drug interactions with area under
the time-plasma concentration curve (AUC) changes ≥5-fold (ie, AUCRs ≥5 or ≤0.2), 2- …

… Regulatory agencies continue to update and evolve their guidance for the conduct of in vitro
… -mediated drug-drug interactions (DDIs). The final guidance released by the Food and Drug …

… of drugs, and hence, drug–drug interactions. In parallel with the growing research interest in
this area, regulatory … hepatic transporter-mediated drug–drug interactions can be taken into …

… Our broader goal – and the specific focus of this paper – is to develop information models
and tools that will provide drug-drug interaction experts with clear and usable views of …

… recommendations for systematic evaluation of evidence for DDIs from the scientific literature,
drug product labeling, and regulatory … This paper describes recommendations by the …