Uptake and efflux transporters determine plasma and tissue concentrations of a broad …
drug-drug interactions attributable to inhibition or induction of intestinal export transporters [P-…

… Well characterized contributions of transporters to drug disposition are the uptake of drugs
… In this section, drug–drug interactions at hepatic efflux transporters are described by the use …

… uptake transporters, their molecular features, their role in transporter-mediated drug–drug
interactions… polymorphisms in transporter genes encoding mutated uptake transporter proteins …

… transporters are responsible for the uptake of … Uptake transporters mediate the uptake of
drugs from the blood into hepatocytes, whereas export pumps actively secret drugs or drug …

… interactions early in the drug development to mitigate clinical risks. Areas covered: The role
of hepatic uptake transporters in drug … predict drug interactions, early in drug discovery, to …

… The average contribution to atorvastatin uptake was OATP1B1 > OATP1B3 >> OATP2B1 >
… in transporter expression and CL upt resulted in marked differences in drug-drug interactions …

… drugs may also result in a change in drug pharmacokinetics. These uptake transporter-mediated
drug–drug interactions … the current in vitro evidence on interactions mediated by OATPs (…

… The aim of this study was to examine the role of intestinal ABC and SLC drug transporters
in regulating atazanavir intestinal permeability and drug-drug interactions. Intestinal …

… The mechanism involved in the clinically relevant drug-drug interaction (DDI) between …
the possible roles of transporter-mediated hepatic uptake in this DDI. The uptake of [ 14 C]CER …

… transporters and solute carrier (SLC) uptake transporters … transporters also have a central
role in the disposition of antiretroviral drugs, and can contribute to many drug–drug interactions …