… drug clearance and the impact of drug−drug interactions (… Further, the oil-spin assay would
also be most suitable for … of hepatocytes to assess potential drug−drug interactions in uptake. …

… This review summarizes current in vitro functional assays of CYP activity to assist in …
immunosuppressive drug-drug interactions. We also present the various in vitro assays used to …

… drugs, which is a major reason for drug-induced toxicity via drug–drug interactions (DDIs).
Thus, the evaluation of potential DDIs is a key aspect of new drug discovery and development. …

… The recent FDA concept paper on drug interactions recommends that new drug candidates
… potential for clinical drug-drug interactions. The existence of multiple drug binding/transport …

… compound usage of in vitro drug interaction assays. Advances in assay miniaturization …
reliability, as well as decreased compound use. Biological markers such as nicotinamide cofactor …

… of drug-botanical interactions is important for the safe use of botanical dietary supplements.
Among the different forms of drug interactions … of drug-drug or drug-botanical interactions. …

… , and inhibitory drug–drug interactions. Dose-… assay for metabolic stability. Known CYP
isoform-specific inhibitors were evaluated in the HTS assay for inhibitory drug–drug interactions. …

… leading to errors in predicting important drug–drug interactions. One solution would be to …
to highlight potential drug–drug interactions is to use three CYP3A4 assays. Selection of a …

… OATP1B1 assays to assess drug transport and the potential for drug–drug interaction to …
This study was undertaken to validate uptake assays utilizing HEK293-OATP1B1 cells and …

… drug metabolism enzyme in humans. Metabolism-based inhibition of CYP3A might cause
clinically significant drug-drug interactions … -dependent inhibition assay. To create a diagram to …