… drugdrug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where we are now and the way forward

G Vijaywargi, S Kollipara, T Ahmed… - … & Drug Disposition, 2023 - Wiley Online Library
… is to understand the drugdrug interaction (DDI) potential of a drug, acting either as victim
or perpetrator when used along with other medications. When such an interaction is present, it …

Drug safety in geriatric patients: current status and proposed way forward

G Furlan, P Caduff-Janosa, L Sottosanti, E Cappello… - Drug Safety, 2020 - Springer
… However, polypharmacy increases the risk of experiencing ADRs due to drugdrug interactions
and interactions between drugs and the patient’s underlying medical conditions and this …

Pharmacogenetics, pharmacogenomics, and cardiovascular therapeutics: the way forward

SG Terra, JA Johnson - American Journal of Cardiovascular Drugs, 2002 - Springer
… Recently, PGP has been implicated as the causative factor in numerous pharmacokinetic
drug interactions.[19] For example, amiodarone and quinidine increase serum digoxin …

[HTML][HTML] Computer-aided drug design in anti-cancer drug discovery: What have we learnt and what is the way forward??

I Opeyemi, O Paul, F Olawale, B Olorunfemi… - Informatics in Medicine …, 2023 - Elsevier
… of anticancer drugs and contribute to optimizing drug dosing regimens, predicting drug
response, and identifying potential drug interactions or toxicities. These modeling approaches …

[HTML][HTML] Drug trials in children: problems and the way forward

S Conroy, J McIntyre, I Choonara… - British journal of clinical …, 2000 - ncbi.nlm.nih.gov
… have been used to study drug interactions and the effect of disease on drug metabolism [23–…
collect blood samples in order to study drug interactions of clinical significance in children. …

Drug-disease and drug-drug interactions: systematic examination of recommendations in 12 UK national clinical guidelines

S Dumbreck, A Flynn, M Nairn, M Wilson, S Treweek… - bmj, 2015 - bmj.com
… Adaptive electronic based guidelines that allow interactive searching for specific conditions
are a potential way forward to account for multimorbidity in guideline recommendations …

[HTML][HTML] Clopidogrel resistance: the way forward

S Ray - indian heart journal, 2014 - Elsevier
… Insufficient metabolite generation secondary to limitations in intestinal absorption, Drug-drug
interaction at CYP 3A4 or genetic polymorphism of CYP isoenzymes are seen as the …

[HTML][HTML] NTM drug discovery: status, gaps and the way forward

ML Wu, DB Aziz, V Dartois, T Dick - Drug discovery today, 2018 - Elsevier
… abscessus, we summarize the current state of NTM drug discovery and development, … in
NTM drug discovery and discuss how to focus research efforts to accelerate building a NTM drug

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

TD Bjornsson, JT Callaghan, HJ Einolf, V Fischer… - Drug metabolism and …, 2003 - ASPET
… in vivo pharmacokinetic drug-drug interaction studies targeted to … Drug-drug interactions can
lead to severe side effects and … Regulators, including the US Food and Drug Administration (…

Learning of clinical pharmacology by future prescribers in Bologna: Teachers' and students' reflections on the way forward

E Poluzzi, E Raschi, C Lunghi… - British Journal of …, 2024 - Wiley Online Library
drug interactions, monitor its safety and eventually stop its administration). Adapting
pharmacological therapy to each patient is an advanced skill for medical students and represents a …