… Knowledge of cytochrome P450 (CYP450) enzyme inhibition profiles and interactions
continues to increase and these data assist in the prediction of drug–drug interactions. It is …

… of anticancer drugs and contribute to optimizing drug dosing regimens, predicting drug
response, and identifying potential drug interactions or toxicities. These modeling approaches …

… drug-drug interactions. Nevertheless, the emerging field of the manipulation of ABC transporter
activity for therapeutic purposes is still in its outset and more studies are needed to fully …

… However, routine TDM of ARVs is not recommended for adults or children, and selective
TDM for special situations, including suspected drug interactions and toxicity or adherence, is …

… The traditional methods and routes of drug administration result in a rate of drug uptake
that is controlled by the drug properties (solubility, charge, molecular size, etc.) and the …

… 5-fluorouracil (5-FU) is a US Food and Drug Administration (FDA)-approved anticancer
drug that is used for the treatment of various types of solid tumors. However, it has a poor …

… Drug side effects play an important role in drug safety. Research on drug adverse effects
helps to unveil cellular disturbances under treatment as well as support drug discovery and …

… Current Computerized Physician Order Entry (CPOE) systems tend to simply alert providers
when doses are outside a defined range or a drug interaction is present, but due to provider “…

… Safety assessments at the nonclinical stage require a critical look at the interactions between
drug components and laboratory test animals way before exposing the dug to humans. …

… Focused, early phase II studies defining dosage, pharmacodynamics, and drug interactions
will improve the likelihood of success for phase III trials. Additionally, understand barriers to …