… drug levels available; once an endpoint was reached, drug … the study (drug levels and dosage
adjustment performed thereafter … were free to adjust the treatment dosage based on their …

… Target concentration intervention is suggested to enable more accurate dose adjustment
because it uses all relevant data on the patient and disease [13]. Such an approach would …

… exposure to drugs for personalized dose adjustment is of … samples have been used for
drug monitoring, which only poses … may improve the feasibility of therapeutic drug monitoring. …

… The assay results should be available quickly, preferably within 24 h of receiving the sample,
as the most important uses of the measurements are during dosage adjustments and in …

… for therapeutic drug monitoring of ISDs and dosing recommendations when … cyclosporine
dosage should be reduced to 20% of the initial dosage during the antiviral treatment. Dosages …

… 5-FU dosing with the main goals of increasing clinical efficacy while reducing drug-associated …
dose adjustment of 5-FU based on plasma 5-FU drug levels is feasible and that PK-based …

… results of therapeutic drug monitoring and pharmacogenetic … drug management prompted
by therapeutic drug monitoring … drug concentration based on metabolic status with the dose …

… for adjustment is then delayed to the next infusion, if any. Moreover, optimal adjustment
could … Current TDM practices are mainly suited for a posteriori dose adjustment, which is …

… , the dose adjustment can be easily derived based on a representative plasma concentration.
In several studies, mostly involving fluorouracil, such a dose-adjustment scheme or …

… , the elderly, patients with associated diseases, drug formulation changes); (5) when a …
an interacting drug is added or removed); (6) to guide dose adjustments for AEDs with dose-…