… More importantly, the HoMS system provides a smart responsive release mechanism that …
diffusion- and physical barrier-driven temporally-spatially ordered drug release, providing a …

… a) An example of numerical modeling of local drug release from the struts of a drug-eluting
stent. Each of the white circular regions in the main image represents a stent strut, which is …

… release studies demonstrated a zero order release from devices with the crosslinked outer
layer. Drug release … the drug release rate should be dependent only upon the permeation …

… in the tumor site, and the drug loading level is 50%, … of the drug be released, this further
reduces the available drug to 2.5%. We have of course yet to construe what rate of drug release …

… physical barriers in the body restrict the quantity of drugs that can pass through, mainly as a
consequence of the barrier … also be exploited as a mechanism to control drug release. This …

… The microenvironment of tumor nodules can generate a number of physical barriers to
resist a wide range of therapeutic agents. These treatment barriers cannot be ignored when …

… can have a large effect on T g and therefore drug release. Chains based on Si–O, P–N, C–C…
increases the drug release because the diffusion coefficient (D) and solubility of the drug in …

… To sustain drug release and maintain therapeutic concentrations at the target site over
prolonged periods, transcorneal iontophoresis has recently been combined with the delivery of …

… materials for barrier navigation. We then discuss essential … barriers and how biointerface
engineering can enable drug carriers to better navigate and overcome these barriers to drug …

… Collectively, these barriers serve to protect the body from invading pathogens and … barriers
also limit our ability to deliver drugs. Accordingly, approaches to knock down these barriers …