[HTML][HTML] Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model

BR Beck, B Shin, Y Choi, S Park, K Kang - Computational and structural …, 2020 - Elsevier
… -based drug-target interaction model called Molecule Transformer-Drug Target Interaction (…
) to identify commercially available drugs that could act on viral proteins of SARS-CoV-2. The …

SARS-CoV-2 protein drug targets landscape: a potential pharmacological insight view for the new drug development

C Chakraborty, M Bhattacharya, B Mallick… - Expert review of …, 2021 - Taylor & Francis
… protein drug targets of SARS-CoV-2 and their structures, including the drug target class and
its … We have also discussed several drug discovery approaches and associated protein drug

[HTML][HTML] Drug discovery strategies for SARS-CoV-2

ZA Shyr, K Gorshkov, CZ Chen, W Zheng - Journal of Pharmacology and …, 2020 - ASPET
… of action may be a practical therapeutic strategy for the treatment of severe COVID-19. …
therapeutics against SARS-CoV-2. This review highlights the anti–SARS-CoV-2 drug targets and …

[HTML][HTML] Genomics insights of SARS-CoV-2 (COVID-19) into target-based drug discovery

P Chellapandi, S Saranya - Medicinal Chemistry Research, 2020 - Springer
… of candidate repurposable drugs and potential drug combinations targeting SARS-CoV-2
using disease-related molecular networks. A systematic drug repurposing approach has been …

RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2

A Mishra, AS Rathore - Journal of Biomolecular Structure and …, 2022 - Taylor & Francis
… RNA polymerase is treated as a principal target for the SARS-CoV2. Its similarity with other
viruses allows us to test the existing antiviral molecule against COVID19. Nucleotide analogs, …

[HTML][HTML] Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

C Wu, Y Liu, Y Yang, P Zhang, W Zhong… - … Pharmaceutica Sinica B, 2020 - Elsevier
… and targets for further in vitro and in vivo studies of SARS-CoV-2, new insights for those …
drug repositioning candidates and targets for further in vitro and in vivo studies of SARS-CoV-2

Drug repurposing studies targeting SARS-CoV-2: an ensemble docking approach on drug target 3C-like protease (3CLpro)

S Koulgi, V Jani, M Uppuladinne… - Journal of …, 2021 - Taylor & Francis
SARS-CoV-2 drug target was screened for probable drug … and SWEETLEAD drug database
(Centre for Drug Evaluation … used for drug repurposing studies against the drug target 3CL …

[HTML][HTML] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
… confidence protein–protein interactions between SARS-CoV-2 and human proteins. Among
targeted by 69 compounds (of which, 29 drugs are approved by the US Food and Drug

[PDF][PDF] A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing

MJ O'Meara, JZ Guo, DL Swaney, TA Tummino… - BioRxiv, 2020 - biorxiv.org
… Identification of existing drugs targeting SARS-CoV-2 human host factors. To identify small
molecules targeting human proteins in the SARS-CoV-2 interactome, we sought ligands …

[HTML][HTML] Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

Y Zhou, Y Hou, J Shen, Y Huang, W Martin, F Cheng - Cell discovery, 2020 - nature.com
… (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and …
drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, representing as an effective drug