M Drozdzik, D Busch, J Lapczuk… - Clinical …, 2019 - Wiley Online Library
… on drugtransporter protein abundance are required in order to estimate contribution of specified intestinal segments and liver to drug … absolute intraindividual protein abundance of drug …
… In conclusion, differences were observed in absoluteabundances measured by several targeted and untargeted methods. Error inherent to these methods was mitigated by measuring …
MD Harwood, B Achour, MR Russell… - … of pharmaceutical and …, 2015 - Elsevier
… This study has optimised LC–MS/MS targeted proteomic methods for quantifying drug transporter protein absoluteabundance using a QconCAT strategy. The methods were applied to …
M Drozdzik, C Gröer, J Penski, J Lapczuk… - Molecular …, 2014 - ACS Publications
… technology, our current knowledge of drugtransporterabundance along the gut is mainly … data for the absolute protein content of multidrug transporters in healthy mucosa of the small …
KWK Cheung, BD van Groen, E Spaans… - Clinical …, 2019 - Wiley Online Library
… In addition, our study also showed much higher absoluteabundance for most proteins in our adult samples compared with other studies.34 As Li et al.35 suggested, such interlaboratory …
N Couto, ZM Al-Majdoub, S Gibson, PJ Davies… - Drug Metabolism and …, 2020 - ASPET
… (UGT)] and drugtransporters were quantified in total mucosal … for drugtransporters did not correlate with the abundance of … reporting absolute enzyme and transporterabundances in …
MD Harwood, M Zhang, SM Pathak, S Neuhoff - Drug Metabolism and …, 2019 - ASPET
… The weighted mean, coefficient of variation, and geometric mean of total membrane protein abundance of drugtransporters in the proximal jejunum (jejunum I) obtained from the meta-…
B Prasad, K Johnson, S Billington, C Lee… - Drug Metabolism and …, 2016 - ASPET
… the major drugtransporters, our study did not include all transporters such as organic anion-transporting polypeptide 4C1, urate transporter 1, and the thiamine transporters. MATE2-K …
O Schaefer, S Ohtsuki, H Kawakami, T Inoue… - Drug Metabolism and …, 2012 - ASPET
… the most abundant among the tested drugtransporters; MRP1, breast cancer resistance protein (BCRP), and OATP1B3 mRNA was found to be the least abundant (data not shown). …