… and the kidneys are the main routes by which drugs and their … The first step in drug elimination
in liver and kidney is uptake … The substrate specificity and affinity of the uptake carriers …

… transporters and to outline the current knowledge with respect to the well-characterized drug
uptake transporters of the … in the kidney and the liver.1 , 2 , 3 , 4 , 5 The transporters that are …

… of drug uptake transporters, which might make the already complex situation even more
challenging. As discussed, studies have shown that many of the drug transporters can form …

… drug transporters expressed in the liver and kidney in rat and human. Bile salt export pump
(Bsep, BSEP) is a primary active transporter … uptake clearance of pravastatin in the kidney per …

… in volume changes following uptake transporter interactions in the kidney and liver: the …
than uptake transporters outside the liver and kidney, despite the fact that uptake transporters are …

… The potential-stimulated PAH uptake was more sensitive to anionic drugs such as furosemide
and 4,… transporters in the brain, retina, liver, and kidney. The membrane localization of both …

… by the postnatal kidneys with the liver is also needed to excrete drugs and metabolites … ;
after basolateral OAT3 uptake, secretion by apical membrane transporters may not be sufficiently …

… Transporters play an important role in the processes of drug absorption, distribution and …
of transporters in drug excretion in the liver and kidney. The rate of transporter-mediated uptake …

… drug uptake into the liver. However, at high intracellular substrate levels the sinusoidal transport
proteins can act as hepatic efflux transporters… Oat1 is predominantly a kidney transporter …

… ) uptake transporters, drug-drug … in the kidneys, the liver and the intestines [28]. In humans,
OCT1 (gene symbol SLC22A1) is present mainly in the liver, where it mediates the uptake of …