… DYRK1A inhibitors, for which the majority of efforts have evolved over the last 5 years. In
this review, … inhibitors, and promiscuous kinase inhibitors subsequently found to possess …

… CDK5, CK1, GSK3, CLK1 and DYRK1A. Introduction of aminoalkylamino groups at the 2-…
nanomolar affinity and selective inhibition of CLK1 and/or DYRK1A. Their evaluation on several …

… In this review, the latest therapeutic potential of DYRK1A for different diseases and the …
This review aims to summarize the recent findings on DYRK1A inhibitors with potential …

… , we decided to verify whether DYRK1A kinase is a molecular … inhibition of DYRK1A by
flavones in biochemical assays. Our X-ray structures confirms flavones interaction with DYRK1A …

… to identify novel DYRK1A inhibitors. In this study, we aim to identify structurally diverse
DYRK1A inhibitors for neurodegenerative diseases by VS and in vitro biological evaluation. As …

… To evaluate the usability of the new DYRK1A inhibitors in cell culture experiments, we
analyzed the effect of AnnH75 and other harmine analogues on the viability of three different …

… DYRK1A inhibitors. The work in this thesis explores the importance of the 7-azaindole
skeleton to DYRK1A inhibition … The sequential selectivity of promising inhibitors over other off-…

… An array of pyrido[3,2-d]pyrimidines was prepared and claimed to inhibit DYRK1A. The patent
assigned to CNRS [Citation39] describes mainly the synthesis and biological evaluation of …

… Furthermore we validated our theoretical model by synthesis and biological evaluation of
several potential DYRK1A inhibitors. The developed pharmacophore model is able to …

… The current review focuses on the implications of DYRK1A in cancer development, … is
paid to compounds that display anticancer activity through the targeting of DYRK1A. …