… Although intense efforts have been made to develop DYRK1A inhibitors, highly potent
and specific inhibitors are still lacking. Many inhibitors of DYRK1A from natural and synthetic …

… Like most tyrosine kinase inhibitors developed up to the market, DYRK1A inhibitors are …
inhibiting the catalytic activity of DYRK1A. Expert opinion: Despite the important role of DYRK1A …

… DYRK1A that may account for its dual specificity kinase activity. For a broad coverage of
chemical scaffolds, we compiled a series of compounds comprising known DYRK1A inhibitors (…

… tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is a new high-potential … novel
potent and selective DYRK1A inhibitor. EHT 5372 inhibits DYRK1A-induced Tau phosphorylation…

… of DYRK1A in diabetes. Here we report a variety of scaffolds not generally known for DYRK1A
inhibition, … These inhibitors effectively block the tau phosphorylation that is a hallmark of …

… -penetrant DYRK1A inhibitor which showed in vivo activity in a tumor model. The inhibitor
provides a useful tool compound for further exploration of the effect of DYRK1A inhibition in …

… Dual specificity tyrosine phosphorylation regulated kinase 1A (… inhibitors, and plays an
irreplaceable role in the design of the compounds. This paper mainly reviews DYRK1A inhibitors …

… Inhibitory effect of DYRK1 inhibitors and transient DYRK1A knockdown, respectively, on
HCMV protein production and viral replication. (A) Inhibitory effect of DYRK inhibitors on …

… We studied the effect of DYRK1A inhibition in HNSCC cell lines. Our study demonstrates that
inhibition of DYRK1A led to cell death via decrease in phosphorylation of FOXO3A which is …

… , which inhibits DYRK1A by interfering with its folding process [254], all reported inhibitors
… Several DYRK1A inhibitors have been reported in recent years (reviews: [88,93,95]) which, …