… Although protein content is lower in cerebrospinal fluid (CSF) than in serum, CSF is an ideal
source for developing viable biomarkers in AD as it directly interacts with the extracellular …

… There is currently a renaissance of interest in the many functions of cerebrospinal fluid (CSF).
Altered flow of CSF, for example, has been shown to impair the clearance of pathogenic …

… in ventricular postmortem cerebrospinal fluid (CSF) of 121 … the aged individuals with early
neuropathological changes in the … melatonin levels may be an early event in the development …

Importance Individuals in the presymptomatic stage of Alzheimer disease (AD) are increasingly
being targeted for AD secondary prevention trials. How early during the normal life span …

… is a valid diagnostic marker that changes during the very early stages of the disease and then
… the early symptomatic phase, together with measurements of brain atrophy, cerebral blood …

… how cerebrospinal fluid (CSF) regulates brain function. More than a protective fluid cushion
and … This review examines the current understanding about early CSF and its maturation and …

… imaging and cerebrospinal fluid (CSF) Aβ1–42 (Aβ42) is an early indicator of preclinical
Alzheimer disease (AD). To better understand their relationship during the earliest preclinical …

… Such biochemical markers would be especially helpful in the early … cerebrospinal fluid (CSF),
biochemical changes in the brain may be reflected by CSF analyses. Cerebrospinal fluid …

… in the development and validation of cerebrospinal fluid (CSF) … , and will also improve
early and differential AD diagnosis … Therefore, a biomarker-based early diagnosis of AD offers …

… (AI) values for the diagnosis of early neuroborreliosis. Basic CSF variables included total
cell … 94% diagnostic specificity, is the earliest marker to disappear following effective therapy. …