Strategies in early clinical development for the treatment of basic defects of cystic fibrosis

B Dhooghe, JB Haaf, S Noel, T Leal - Expert Opinion on …, 2016 - Taylor & Francis
… of the gene responsible for cystic fibrosis (CF), controversies … of fundamental therapies in
early stages of development for … compounds being currently tested are in very early (I-II) phases …

Roadmap for an early gene therapy for cystic fibrosis airway disease

MS Carlon, D Vidović, S Birket - Prenatal Diagnosis, 2017 - Wiley Online Library
cystic fibrosis (CF). CF is a chronic autosomal recessive genetic disorder caused by mutations
in the cystic fibrosis … the median age at death remains early thirties.7 The pathophysiology …

[HTML][HTML] Year-to-year changes in lung function in individuals with cystic fibrosis

TG Liou, EP Elkin, DJ Pasta, JR Jacobs… - … of Cystic Fibrosis, 2010 - Elsevier
… uniform numbers of repeated measurements each year, by the effects of differing methods
of FEV 1 % calculation, and by the effects of early censoring from the study due to loss to follow…

Lung function is abnormal in 3-month-old infants with cystic fibrosis diagnosed by newborn screening

…, J Stocks, London Cystic Fibrosis Collaboration - Thorax, 2012 - thorax.bmj.com
… Is lung function normal at 3 months of age in infants with cystic fibrosis (CF) diagnosed via …
of airway function in early childhood following clinical diagnosis of cystic fibrosis. Am J Respir …

Early detection of lung function abnormalities in infants with cystic fibrosis.

R Kraemer - Journal of the Royal Society of Medicine, 1989 - ncbi.nlm.nih.gov
… ) in cystic fibrosis. J Pediatr 1987;111:599-605. Schoeni HM, Kraemer R, Baehler P, Rossi
E… Early diagnosis of cystic fibrosis by means of sweat microosmometry. J Pediatr 1984;104:…

Progression of early structural lung disease in young children with cystic fibrosis assessed using CT

LS Mott, J Park, CP Murray, CL Gangell, NH de Klerk… - Thorax, 2012 - thorax.bmj.com
Cystic Fibrosis Foundation, Australia. The full authorship includes the following members of
the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (… in early cystic fibrosis. …

Early antibiotic treatment of pseudomonas aeruginosa colonisation in cystic fibrosis: a critical review of the literature

F Marchetti, L Giglio, M Candusso, D Faraguna… - European journal of …, 2004 - Springer
… of pulmonary damage in patients with cystic fibrosis (CF) has … defect in the cystic fibrosis
transmembrane conductance … score were no different in early-colonised patients compared …

Newborn screening for cystic fibrosis

, … Cystic Fibrosis and Genetic Disorders … - Cochrane Database …, 1996 - cochranelibrary.com
cystic fibrosis lung disease and malnutrition occur very early in life. These complications are
suited to early … therefore improve outcomes for people with cystic fibrosis. We aimed to find …

Diagnosis and early life risk factors for bronchiectasis in cystic fibrosis: a review

PD Sly, CE Wainwright - Expert Review of Respiratory Medicine, 2016 - Taylor & Francis
… in cystic fibrosis begins in early … in early life but require a better understanding of how
bronchiectasis develops. Areas covered: In this review we have addressed the diagnosis and early

Early Childhood Risk Factors for Decreased FEV1 at Age Six to Seven Years in Young Children with Cystic Fibrosis

DB Sanders, J Emerson, CL Ren… - Annals of the …, 2015 - atsjournals.org
… the progression of cystic fibrosis (CF) lung disease. Objectives: To evaluate early childhood
… Growth and nutritional indexes in early life predict pulmonary function in cystic fibrosis. J …