Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography

TAM Bharat, T Noda, JD Riches… - Proceedings of the …, 2012 - National Acad Sciences
… tomography to visualize Ebola virus particles, as well as Ebola virus-like particles, in … virus
shows that the N-terminal region of nucleoprotein defines the inner diameter of the Ebola virus

Structure and assembly of the Ebola virus nucleocapsid

W Wan, L Kolesnikova, M Clarke, A Koehler, T Noda… - Nature, 2017 - nature.com
… the structural data obtained using VLPs, we purified Ebola virus and Marburg virus particles
(… We obtained a structure for the Ebola virus NC in which the NP layer was resolved at 9.1 Å (…

Structural and functional aspects of Ebola virus proteins

S Jain, E Martynova, A Rizvanov, S Khaiboullina… - Pathogens, 2021 - mdpi.com
… -workers, including the virus circulating in Chinese bats, named Měnglà virus (MLAV) (Figure …
terminology, the Ebola virus (EBOV) is a Zaire ebolavirus species in the Ebolavirus genus. …

Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-Å resolution

VN Malashkevich, BJ Schneider… - Proceedings of the …, 1999 - National Acad Sciences
… Previously, we used a protein-dissection strategy to identify and determine the x-ray structures
of protease-resistant cores for viral proteins involved in membrane fusion, including those …

[PDF][PDF] Protein dissection of the Ebola virus glycoprotein

BJ Schneider - 1998 - oastats.mit.edu
… which are then used for X-ray crystal structure determination. This study represents the protein
dissection of a 95 amino acid fragment of the Ebola virus GP2 (Figure 1). After expressing …

Electron cryo-microscopy structure of Ebola virus nucleoprotein reveals a mechanism for nucleocapsid-like assembly

Z Su, C Wu, L Shi, P Luthra, GD Pintilie, B Johnson… - Cell, 2018 - cell.com
… the effect on viral RNA synthesis. Additionally, we compare our structural observations with
virus-like particle (VLP) structure at sub-nanometer resolution by electron cryo-tomography ( …

Insight into the Ebola virus nucleocapsid assembly mechanism: crystal structure of Ebola virus nucleoprotein core domain at 1.8 Å resolution

S Dong, P Yang, G Li, B Liu, W Wang, X Liu, B Xia… - Protein & …, 2015 - academic.oup.com
Ebola virus (EBOV) is a key member of Filoviridae family and causes severe human infectious
… on the extension parts of EBOV NP is necessary to dissect its precise biological roles. …

Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle

ZA Bornholdt, T Noda, DM Abelson, P Halfmann… - Cell, 2013 - cell.com
… Here, we set out to provide a structurally and biologically … the different roles played by VP40
in the ebolavirus life cycle. … structures of dimeric VP40, from Ebola virus and Sudan virus, …

Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex at 3.6 Å resolution

Y Sugita, H Matsunami, Y Kawaoka, T Noda, M Wolf - Nature, 2018 - nature.com
… Here we report the structure of a recombinant Ebola virus nucleoprotein–RNA complex …
Our structure reveals how the Ebola virus nucleocapsid core encapsidates its viral genome, its …

Structure‐function analysis of the soluble glycoprotein, sGP, of ebola virus

D Falzarano, O Krokhin, V Wahl‐Jensen… - …, 2006 - Wiley Online Library
… Glycoprotein dissection: Despite intensive investigation, the roles of the glycoproteins that
are secreted during Ebola infection are still unknown. Here we clearly demonstrate that the …