Effect of dapagliflozin on cardiovascular outcomes according to baseline kidney function and albuminuria status in patients with type 2 diabetes: a prespecified …

TA Zelniker, I Raz, O Mosenzon, JP Dwyer… - JAMA …, 2021 - jamanetwork.com
effect of dapagliflozin on the relative risk for CV events was consistent across kidney function
and albuminuria status, … both reduced estimated glomerular filtration rate and albuminuria. …

The effect of dapagliflozin on albuminuria in DECLARE-TIMI 58

O Mosenzon, SD Wiviott, HJL Heerspink… - Diabetes …, 2021 - Am Diabetes Assoc
… We used Kaplan-Meier curves to demonstrate the risk of deterioration in categorical albuminuria
status over time and compared between treatment arms using a log-rank test. In addition…

Dapagliflozin reduces albuminuria over 2 years in patients with type 2 diabetes mellitus and renal impairment

P Fioretto, BV Stefansson, E Johnsson, VA Cain… - Diabetologia, 2016 - Springer
… Furthermore, changes in albuminuria predict morbidity and … short-term beneficial effect of
dapagliflozin on albumin excretion … The shift in albuminuria status was assessed from baseline …

Effect of dapagliflozin on urinary albumin excretion in patients with chronic kidney disease with and without type 2 diabetes: a prespecified analysis from the DAPA …

N Jongs, T Greene, GM Chertow… - The lancet Diabetes & …, 2021 - thelancet.com
… We assessed the effects of dapagliflozin on albuminuria in patients with chronic kidney …
on these endpoints by baseline type 2 diabetes status. For these analyses, we removed type 2 …

Effect of dapagliflozin on cardiac function in people with type 2 diabetes and albuminuria–A double blind randomized placebo-controlled crossover trial

MK Eickhoff, FJ Olsen, M Frimodt-Møller, LJ Diaz… - Journal of Diabetes and …, 2020 - Elsevier
… found several indications that dapagliflozin treatment led to changes in volume status. Of
note… lithium excretion increased, indicating that dapagliflozin had osmotic and natriuretic effects. …

Reduction in albuminuria with dapagliflozin cannot be predicted by baseline clinical characteristics or changes in most other risk markers

HJL Heerspink, CD Sjöström… - Diabetes, Obesity …, 2019 - Wiley Online Library
… trials (Table S1) assessing the effect of dapagliflozin 10 mg/d or placebo administered for …
of these variables could predict future responder status. Moreover, the similarity in baseline …

Albuminuria-lowering effect of dapagliflozin, eplerenone, and their combination in patients with chronic kidney disease: a randomized crossover clinical trial

M Provenzano, MJ Puchades, C Garofalo… - Journal of the …, 2022 - journals.lww.com
… that the albuminuria-lowering effects of dapagliflozin and … albuminuria reduction of 53%
after 4 weeks of dapagliflozin-… subgroups defined by diabetes status and baseline eGFR. In …

Effects of the SGLT2 inhibitor dapagliflozin on proteinuria in non-diabetic patients with chronic kidney disease (DIAMOND): a randomised, double-blind, crossover trial

DZI Cherney, CCJ Dekkers, SJ Barbour… - The lancet Diabetes & …, 2020 - thelancet.com
… SGLT2 inhibition decreases albuminuria and reduces the risk of … the kidney effects of the
SGLT2 inhibitor dapagliflozin in … 6-week treatment with dapagliflozin did not affect proteinuria in …

Effects of dapagliflozin on volume status and systemic haemodynamics in patients with chronic kidney disease without diabetes: Results from DAPASALT and …

T Sen, R Scholtes, PJ Greasley… - Diabetes, Obesity …, 2022 - Wiley Online Library
… the effects of 6 weeks of dapagliflozin on markers of volume status in 53 patients with CKD.
… of the study was difference in 24-hour proteinuria between dapagliflozin and placebo. …

Prediction of the effect of dapagliflozin on kidney and heart failure outcomes based on short-term changes in multiple risk markers

NMA Idzerda, BV Stefansson, MJ Pena… - Nephrology Dialysis …, 2020 - academic.oup.com
… that even with a smaller albuminuria-lowering effect of dapagliflozin (10% instead of the …
of brain natriuretic peptide as a marker for volume status instead of body weight, as the latter …