Pre-erythrocytic malaria vaccines: towards greater efficacy

AVS Hill - Nature Reviews Immunology, 2006 - nature.com
… current malaria vaccine reaches the levels of durable efficacy likely to be required for vaccine
… -liver-stage vaccines in combination produces much greater efficacy and this combination …

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine

R Webster, S Sekuloski, A Odedra, S Woolley… - BMC medicine, 2021 - Springer
… to malaria vaccine development. We aimed to develop a genetically attenuated blood-stage
vaccine and test its safety, … -stage GAP malaria vaccine and characterize its safety, infectivity, …

Safety and immunogenicity of RTS, S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial

L Otieno, M Oneko, W Otieno, J Abuodha… - The Lancet Infectious …, 2016 - thelancet.com
… not contain clinical data for administration of a malaria-vaccine candidate in a confirmed HIV-…
report safety and immunogenicity results of a malaria vaccine in an HIV-infected population. …

Safety and immunogenicty of RTS, S/AS02A candidate malaria vaccine in Gambian children

KA Bojang, F Olodude, M Pinder, O Ofori-Anyinam… - Vaccine, 2005 - Elsevier
malaria occurs in young children [5]. In order to ultimately evaluate the safety and efficacy of
the RTS,S/AS02A candidate vaccine … escalation and dose escalation safety trials in children. …

Efficacy of RTS, S malaria vaccines: individual-participant pooled analysis of phase 2 data

P Bejon, MT White, A Olotu, K Bojang… - The Lancet infectious …, 2013 - thelancet.com
Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-…
Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic …

Malaria vaccine developments

VS Moorthy, MF Good, AVS Hill - The lancet, 2004 - thelancet.com
… for other diseases are being evaluated first in malaria. We describe progress in malaria
vaccine development in the past 5 years: reasons for cautious optimism, the type of vaccine that …

Duration of vaccine efficacy against malaria: 5th year of follow-up in children vaccinated with RTS, S/AS02 in Mozambique

JJ Campo, J Sacarlal, JJ Aponte, P Aide… - Vaccine, 2014 - Elsevier
malaria when used along with other measures [3]. A minimally 50% efficacious malaria
vaccine that lasts at least a year is critical to the 2015 landmark goals of the Malaria Vaccine

Advances in malaria vaccine development: report from the 2017 malaria vaccine symposium

CH Coelho, JYA Doritchamou, I Zaidi, PE Duffy - npj Vaccines, 2017 - nature.com
Malaria Vaccine Symposium. In this meeting report, we highlight the progress on different
malaria vaccine … and genetic findings that may impact malaria vaccine responses and efficacy. …

Long-term efficacy and immune responses following immunization with the RTS, S malaria vaccine

JA Stoute, KE Kester, U Krzych… - The Journal of …, 1998 - academic.oup.com
… The RTS,S malaria vaccine formulations we studied were designed to induce strong
immune responses to the P. falciparum CS antigen. Our data indicate that antibody and cellular …

Malaria vaccines since 2000: progress, priorities, products

PE Duffy, J Patrick Gorres - npj Vaccines, 2020 - nature.com
… In this Perspective, we examine the background and rationale for different malaria vaccine
… of several of the most prominent malaria vaccines in or nearing clinical trials since the year …