SARS-CoV-2 spike protein 1 activates microvascular endothelial cells and complement system leading to platelet aggregation

L Perico, M Morigi, M Galbusera, A Pezzotta… - Frontiers in …, 2022 - frontiersin.org
spike protein were found in the 30.4% of severe COVID-19 patients. In vitro, the activation of
endothelial cells with S1 protein, … C5b-9 deposition on endothelial cells, along with C3a and …

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein

GJ Nuovo, C Magro, T Shaffer, H Awad, D Suster… - Annals of diagnostic …, 2021 - Elsevier
… induced by complement and cytokine mediated endothelial damage triggered by circulating
… of the spike protein alone (without infectious virus) on human endothelial cells in culture and …

SARS-CoV-2 spike protein induces degradation of junctional proteins that maintain endothelial barrier integrity

S Raghavan, DB Kenchappa, MD Leo - Frontiers in cardiovascular …, 2021 - frontiersin.org
… -2 spike protein binds to the ACE2 receptor in endothelial cells … of critical proteins that
maintain endothelial barrier function … cells and in healthy mouse cerebral arteries, spike protein

Endothelial cell activation by SARS-CoV-2 spike S1 protein: a crosstalk between endothelium and innate immune cells

BM Rotoli, A Barilli, R Visigalli, F Ferrari, V Dall'Asta - Biomedicines, 2021 - mdpi.com
… of mice, thus affecting the endothelial barrier function [41]. Taken … the endothelium.
Interestingly, the activation we observed upon the exposure of endothelial cells to the spike protein

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication

AC Montezano, LL Camargo, S Mary, KB Neves… - Scientific Reports, 2023 - nature.com
… S1 protein induces endothelial inflammation and cell damage independently of viral
infection To study the global effect of SARS-CoV-2 spike protein on endothelial cell protein

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

JP Robles, M Zamora, E Adan-Castro… - Journal of Biological …, 2022 - ASBMB
… Peripheral blood leukocytes were incubated for 1 h with human umbilical vein
endothelial cells (HUVECs) pretreated for 16 h with spike, the receptor-binding domain of …

Endothelial cells are not productively infected by SARS‐CoV‐2

L Schimmel, KY Chew, CJ Stocks… - Clinical & …, 2021 - Wiley Online Library
… SARS-CoV-2 nucleocapsid protein in SARS-CoV-2-treated endothelial cells by … 2 spike
protein can induce the breakdown of the vascular barrier in brain microvascular endothelial cells. …

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants

JUG Wagner, D Bojkova, M Shumliakivska… - Basic Research in …, 2021 - Springer
… levels of spike protein in any of the endothelial cells studied … endothelial cell found to be
positive for spike protein. Together these data suggest that only coronary artery endothelial cells

[HTML][HTML] SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells

YJ Suzuki, SI Nikolaienko, VA Dibrova, YV Dibrova… - Vascular …, 2021 - Elsevier
… Our results show that the SARS-CoV-2 spike protein is … smooth muscle and endothelial cells,
which suggests that cell growth … and endothelial cells revealed that the SARS-CoV-2 spike

SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE 2

Y Lei, J Zhang, CR Schiavon, M He, L Chen… - Circulation …, 2021 - Am Heart Assoc
… SARS-CoV-1 S protein promotes lung injury by decreasing the … that S protein alone can
damage vascular endothelial cells (… a pseudovirus expressing S protein (Pseu-Spike) to Syrian …