Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches

Y Jin, W Ji, H Yang, S Chen, W Zhang… - Signal transduction and …, 2020 - nature.com
… Accumulating evidence indicates that SARS-CoV-2 infection exerts adverse effects on the
endothelium of capillary, which may contribute to COVID-19 pathogenesis by altering the …

Is the endothelium the missing link in the pathophysiology and treatment of COVID-19 complications?

P Castro, M Palomo, AB Moreno-Castaño… - … drugs and therapy, 2022 - Springer
… properties of the endothelium, which may contribute to the … in COVID-19 [26], which acts by
digesting the endothelial cell glycocalyx. This layer covers the luminal face of the endothelium

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic …

PC Evans, GE Rainger, JC Mason… - Cardiovascular …, 2020 - academic.oup.com
endothelium and contribute to endothelial inflammation and dysfunction. In some patients
with COVID-19, severe microvascular endothelial … in COVID-19 improves endothelial function, …

Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

L Ruhl, I Pink, JF Kühne, K Beushausen… - Signal transduction and …, 2021 - nature.com
endothelial contribution to severe COVID-19 our study aimed to investigate a potential link
between the endothelium … and endothelial signatures as main drivers for severe COVID-19

[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Z Qin, F Liu, R Blair, C Wang, H Yang, J Mudd… - Theranostics, 2021 - ncbi.nlm.nih.gov
… Our results suggest that SARS-CoV-2-mediated direct EC infection and indirect EC
dysfunction may contribute to the pathogenesis of COVID-19. These results also indicate that …

Endothelial injury in COVID-19 and acute infections: putting the pieces of the puzzle together

JH Levy, T Iba, EE Gardiner - Arteriosclerosis, Thrombosis, and …, 2021 - Am Heart Assoc
… of organ injury in severe COVID-19. They investigated the contribution of endotheliopathy to
… by examining biomarkers of endothelial damage from 82 COVID-19 patients on admission …

Association of COVID19 with impaired endothelial glycocalyx, vascular function and myocardial deformation 4 months after infection

V Lambadiari, A Mitrakou, A Kountouri… - European journal of …, 2021 - Wiley Online Library
… According to our data, oxidative stress appears the main factor contributing to vascular
dysfunction in our COVID-19 patients as it was 10-fold higher compared to hypertensives and …

Endothelial dysfunction and thrombosis in patients with COVID-19—brief report

S Nagashima, MC Mendes… - … , and vascular biology, 2020 - Am Heart Assoc
… that pyroptosis could contribute to the endothelial cell death after … endothelial tissue
expression of caspase-1 in the COVID-19 … of the pyroptosis in capillary-alveolar endothelial cells. …

Endothelial dysfunction in acute and long standing COVID19: A prospective cohort study

E Oikonomou, N Souvaliotis, S Lampsas, G Siasos… - Vascular …, 2022 - Elsevier
COVID-19 patients develop a notable endothelial dysfunction, which is progressively improved
over … Whether chronic dysregulation of endothelial function following COVID-19 could be …

Endothelial immunity trained by coronavirus infections, DAMP stimulations and regulated by anti-oxidant NRF2 may contribute to inflammations, myelopoiesis, COVID …

Y Shao, J Saredy, K Xu, Y Sun, F Saaoud… - Frontiers in …, 2021 - frontiersin.org
… , suggesting that TI is a significant mechanism for enhancement of endothelial contributions
of cytokine storms and thromboembolism to COVID-19 (SARS-CoV2-induced disease) (131) …