… protein promotes lung injury by decreasing the level of ACE2 in the … damage vascular
endothelial cells (ECs) by downregulating ACE2 and consequently inhibiting mitochondrial function…

… SARS-CoV-2 entry via ACE2 causes downregulation of membrane-bound ACE2 and
concurrent loss of catalytic activity of ACE2 in the RAS system [100]. Therefore, SARS-CoV-2 by …

… NF-κB hyperactivation then promotes a positive feedback cycle between cytokine storm,
endothelial dysfunction, and tissue damage in the microcirculatory environment. BKB- 2 R, …

… , with high affinity, ACE2 present on the surface of … -ACE2 complex can potentially lead to
ACE2 downregulation and shedding from the surface of the cell (24). This loss of ACE2 function …

… Downregulation of ACE2 also promotes inflammation, coagulation, and endothelial dysfunction…
from an animal study of the downregulation of ACE2 has triggered the development of …

… SIRT6 and ACE2. We found that ACE2 is involved in CC-induced endothelial dysfunction,
which inhibits decreases in nitric oxide (NO) level and endothelial nitric oxide synthase (eNOS…

… ACE2 has proven role in the maintenance of endothelial … ACE2 as cell entry receptor)
suggested that virus binding can downregulate ACE2, thus can induce endothelial dysfunction. …

… To confirm the involvement of endothelial injury, we examined lung tissues from a COVID-19
patient and an age-matched control for evidence of apoptosis using cleaved caspase-3 (c-…

… The vascular endothelial dysfunction observed in aortic rings from rats with myocardial
infarction was also reversed by the chronic infusion of Ang-(1–7) [75]. Relatively, a study revealed …

… endothelial dysfunction, such as acute respiratory distress syndrome (ARDS), suggests that
endothelial (… Additionally, intravenous recombinant angiotensin converting enzyme 2 (ACE2) …