Cerebrospinal fluid metabolomics highlights dysregulation of energy metabolism in overt hepatic encephalopathy

N Weiss, PB Saint Hilaire, B Colsch, F Isnard… - Journal of …, 2016 - Elsevier
… Our results also provide new findings regarding the alteration of brain energy metabolism
in HE by investigating what happens in patients. The alteration of energy metabolism in HE …

Coefficient of energy balance, a new parameter for basic investigation of the cerebrospinal fluid

P Kelbich, A Hejčl, IS Krulichová… - Clinical Chemistry and …, 2014 - degruyter.com
… Background: The concentrations of glucose and lactate in cerebrospinal fluid (CSF) provide
important information about energy metabolism in the CSF compartment. To improve our …

Associations of fatty acids in cerebrospinal fluid with peripheral glucose concentrations and energy metabolism

R Jumpertz, A Guijarro, RE Pratley, CC Mason… - PLoS …, 2012 - journals.plos.org
… , in regulating peripheral glucose and energy metabolism. Thus, we hypothesized that …
energy expenditure in humans. To test this we measured FA species profiles in cerebrospinal fluid

Metabolomic analysis of cerebrospinal fluid indicates iron deficiency compromises cerebral energy metabolism in the infant monkey

R Rao, K Ennis, G Oz, GR Lubach, MK Georgieff… - Neurochemical …, 2013 - Springer
… effects, particularly on energy metabolism and myelination [5, 6]. … iron status, for example,
via cerebrospinal fluid (CSF), for … multiple metabolites indexing energy metabolism, neuronal …

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …

ECB Johnson, EB Dammer, DM Duong, L Ping… - Nature medicine, 2020 - nature.com
cerebrospinal fluid in early stages of the disease. In this study of >2,000 brains and nearly
400 cerebrospinal fluid … may serve as therapeutic targets and fluid biomarkers for the disease. …

Physiology and pathophysiology of organic acids in cerebrospinal fluid

GF Hoffmann, W Meier‐Augenstein… - … inherited metabolic …, 1993 - Wiley Online Library
… of organic acids in cerebrospinal fluid (CSF) appear to be … removing these products of cerebral
metabolism. Concentrations of … to carbohydrate and energy metabolism and to amino acid …

Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression

WT Regenold, P Phatak, MJ Makley, RD Stone… - Journal of the …, 2008 - Elsevier
… CNS energy metabolism and MS disease progression by measuring cerebrospinal fluid (…
from two extra-mitochondrial pathways of glucose metabolism, the polyol pathway (sorbitol and …

Cerebrospinal fluid markers of disturbed brain cell metabolism

G Ronquist, A Terent - Progress in Neurobiology, 1982 - Elsevier
… of the body such energy is stored and transmitted by high energy phosphate bonds such
as … substrate and of oxygen for its energy metabolism. The metabolic rate is high and the …

Cerebrospinal fluid ATP metabolites in multiple sclerosis

G Lazzarino, AM Amorini… - Multiple Sclerosis …, 2010 - journals.sagepub.com
… Thus, the indirect evidence for an impaired ATP metabolism from our study could be related
… indicate dysfunction of the mitochondrial energy metabolism, reduced NAA synthesis, and …

Central nervous system metabolism in autism, epilepsy and developmental delays: a cerebrospinal fluid analysis

D Brister, BA Werner, G Gideon, PJ McCarty, A Lane… - Metabolites, 2022 - mdpi.com
… with EPI have looked at blood, cerebrospinal fluid (CSF) and post-… metabolism with a
consistent finding of increased glutamate [10,11,12]. Changes in fatty acid and energy metabolism