… Together, these data indicate that these IMiDs potentiate T cell cytokine production by a
mechanism that involves enhancement of AP-1 transcriptional activity, but without affecting many …

The immunomodulatory drugs (IMiDs) lenalidomide and actimid (also known as CC‐4047)
are thalidomide analogues which are more potent than their parental compound. In …

… Enhancement of cytokine production and AP-1 transcriptional activity in T cells by
thalidomide-related immunomodulatory drugs. J Pharmacol Exp Therap 2003; 305: 1222–1232. …

… toxicity while maintaining or enhancing therapeutic efficacy. This … cytokine production by
macrophages or dendritic cells. [ 38 ] Finally, cytokine stimulation can be further enhanced (or …

… cell differentiation, cytokine secretion, and anti-aging ability are influenced by the other …
enhanced the secretion of several immunomodulatory factors, such as TGF-β1, PGE 2, and IL-6, …

… (CNS); cytokines cause the brain to produce neurochemical, … Abnormal cytokine production
has been demonstrated in … inhibited or enhanced by other cytokines, hormones, and cytokine-…

… on immunostimulatory nonantibiotic agents capable enhancing host … Certain cytokines
stimulate the production of other cytokines … Local and systemic effects of cytokines produced by …

… We evaluated ex vivo the effects of low doses of the immunomodulatory drugs (IMiDs) …
these drugs increased CD4 + and CD8 + T-cell proliferation and cytokine production, enhanced …

… on immunostimulatory agents capable of enhancing host … IL-18 is involved in regulation of
cytokine production during … NK cells to produce immunomodulating cytokines are unknown. …

… In general, the IMiDs have an inhibitory effect on cytokines secreted by stimulated monocytes
but a stimulatory effect on cytokine production by stimulated T cells. The mechanism by …