Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

WS Lee, AK Wheatley, SJ Kent, BJ DeKosky - Nature microbiology, 2020 - nature.com
… acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being … SARS-CoV and
other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

AM Arvin, K Fink, MA Schmid, A Cathcart, R Spreafico… - Nature, 2020 - nature.com
coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2… , and their potential implications for SARS-CoV-2 infection. At …

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

S Matsuyama, N Nao, K Shirato… - Proceedings of the …, 2020 - National Acad Sciences
… VeroE6/TMPRSS2 cells are superior to other cell lines tested in this study for SARS-CoV-2
isolation. Consistent with previous reports (2, 4), the amount of SARS-CoV-2 RNAs in the …

[HTML][HTML] Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies

DO Ricke - Frontiers in immunology, 2021 - frontiersin.org
MERS-CoV), and other coronavirus has been difficult to create due to vaccine induced
enhanced … Multiple betacoronaviruses including SARS-CoV-2 and SARS-CoV-1 expand cellular …

Multiple routes of antibody-dependent enhancement of SARS-CoV-2 infection

K Okuya, T Hattori, T Saito, Y Takadate… - Microbiology …, 2022 - Am Soc Microbiol
… Antibody-dependent enhancement (ADE) of infection is … coronavirus 2 (SARS-CoV-2)
infection has also been discussed since the beginning of the coronavirus disease 2019 (COVID-19

Implications of antibody-dependent enhancement of infection for SARS-CoV-2 countermeasures

N Eroshenko, T Gill, MK Keaveney, GM Church… - Nature …, 2020 - nature.com
… in SARS-CoV-2 should be urgently resolved using experimental immunology. For example,
measuring cross-reactivity of antibodies of unexposed individuals to SARS-CoV-2 could …

Enhanced SARS-CoV-2 neutralization by dimeric IgA

Z Wang, JCC Lorenzi, F Muecksch, S Finkin… - Science translational …, 2021 - science.org
… to SARS-CoV-2 in a cohort of 149 convalescent individuals after diagnosis with COVID-19.
IgA … Plasma IgA monomers specific to SARS-CoV-2 proteins were demonstrated to be twofold …

[PDF][PDF] An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

Y Liu, WT Soh, J Kishikawa, M Hirose, EE Nakayama… - Cell, 2021 - cell.com
… of enhancing antibodies using authentic SARS-CoV-2 virus. The replication of the authentic
SARS-CoV-2 … more than four times in the presence of enhancing antibodies (Figure 3C). …

[PDF][PDF] In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

D Li, RJ Edwards, K Manne, DR Martinez, A Schäfer… - Cell, 2021 - cell.com
… However, using monkey and mouse models of SARS-CoV-2 infection, none of the in vitro
infection-enhancing Abs enhanced SARS-CoV-2 virus replication or infectious virus in the lung …

Antibody-dependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS

MS Yip, HL Leung, PH Li, CY Cheung, I Dutry… - Hong Kong Medical …, 2016 - hub.hku.hk
… Following previous observations made with human immune cell lines,2 we determined
whether ADE of SARS-CoV infection could occur also in primary human immune cells. To …