Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein

M Yalcinkaya, W Liu, MN Islam, AG Kotini… - Scientific reports, 2021 - nature.com
… In conclusion, E-protein decreases NLRP3 inflammasome priming and activation and
reduces pulmonary macrophage content, consistent with reduced inflammasome mediated …

Dengue virus envelope protein domain III induces Nlrp3 inflammasome-dependent NETosis-mediated inflammation in mice

TS Lien, DS Sun, SC Hung, WS Wu… - Frontiers in …, 2021 - frontiersin.org
Nlrp3 inflammasome is involved in rEIII-induced neutrophil death. Accordingly, Nlrp3 inhibitor
OLT1177 and inflammasome… characterizations of whether Nlrp3 inflammasome is involved …

Exposure to dengue envelope protein domain III induces Nlrp3 inflammasome-dependent endothelial dysfunction and hemorrhage in mice

TS Lien, DS Sun, CY Wu, HH Chang - Frontiers in immunology, 2021 - frontiersin.org
… suppression of the Nlrp3 inflammasome through inhibition would … As shown in Figure 4B,
Nlrp3 inflammasome inhibitors … To clarify whether ROS and Nlrp3 inflammasome activate …

[HTML][HTML] Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

JL Nieto-Torres, C Verdiá-Báguena… - Virology, 2015 - Elsevier
… Severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein is a …
Collectively, these results indicate that SARS-CoV E protein activates the NLRP3 inflammasome

Exposure of platelets to dengue virus and envelope protein domain III induces Nlrp3 inflammasome-dependent platelet cell death and thrombocytopenia in mice

TS Lien, H Chan, DS Sun, JC Wu, YY Lin… - Frontiers in …, 2021 - frontiersin.org
NLRP3 inflammasome inhibition prevents a wide range of … inhibitors against Nlrp3
inflammasome displayed rescue … in mice, suggesting that Nlrp3 inflammasome is a potential target …

Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome

RA Khan, S Afroz, G Minhas, S Battu, N Khan - Cytokine, 2019 - Elsevier
… investigated whether NLRP3 inflammasome activation … protein and probed for the expression
levels of NLRP3. Immunoblotting results show that DEN 2 EDIII treatment induces NLRP3

[HTML][HTML] Targeting the NLRP3 inflammasome in severe COVID-19

TL Freeman, TH Swartz - Frontiers in immunology, 2020 - frontiersin.org
NLRP3) inflammasome, and cytokine release syndrome or cytokine storm in this pathogenesis
(9–12). The NLRP3 inflammasome … CoV 3a protein activates the NLRP3 inflammasome in …

[HTML][HTML] NLRP3 inflammasome—a key player in antiviral responses

C Zhao, W Zhao - Frontiers in immunology, 2020 - frontiersin.org
… the NLRP3 inflammasome. In this review, we will focus on the crosstalk between the NLRP3
inflammasome … of viral infection-induced NLRP3 inflammasome activation, and the immune …

The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection

JV Rajan, D Rodriguez, EA Miao, A Aderem - Journal of virology, 2011 - Am Soc Microbiol
… different inflammasome complexes have been identified, but the NLRP3 inflammasome
is … Recent work has demonstrated an essential role for the NLRP3 inflammasome in host …

Dengue virus M protein promotes NLRP3 inflammasome activation to induce vascular leakage in mice

P Pan, Q Zhang, W Liu, W Wang, Z Lao… - Journal of …, 2019 - Am Soc Microbiol
… The amphipathic helical portion interacts with envelope protein (E) to … the NLRP3
inflammasome. Next, we explored which DENV protein plays the crucial role in NLRP3